补体系统作为新冠肺炎患者治疗的潜在靶点

Gilda Parsamanesh, Pooya Farhangnia, M. Karimi, Amirhossein Khosrozadeh Ghomi, Shiva Dehrouyeh, Azin Aghamajidi
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引用次数: 0

摘要

由严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)引起的新发COVID-19已被提出为全球卫生挑战。尽管COVID-19疫苗的开发取得了突破,但它仍然是世界范围内的严重危机。异常的免疫反应与疾病的严重程度以及COVID-19患者发病率和死亡率的增加密切相关。补体级联激活由经典、凝集素和其他途径介导,在COVID-19感染期间可能诱导炎症状态。越来越多的研究表明,补体系统激活在SARS-CoV-2的免疫发病机制中起着重要作用。因此,阻断补体级联可能是预防COVID-19多器官并发症的有效途径。在这篇综述中,我们将重点介绍补体系统在COVID-19免疫病理中的作用,并强调改善COVID-19感染的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complement system as the potential therapeutic target in the management of COVID-19 patients
The emerging COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been raised as a global health challenge. Despite the breakthrough in the development of the COVID-19 vaccine, it still continues as a serious crisis, worldwide. The aberrant immune responses are strongly associated with the severity of the disease and an increased rate of morbidity and mortality among COVID-19 patients. The complement cascade activation is mediated by classical, lectin, and alternative pathways which could induce an inflammatory state during the COVID-19 infection. The growing body of research suggests that complement system activation plays an important role in the immunopathogenesis of SARS-CoV-2. Therefore, the blockade of complement cascades may be an effective approach to prevent the multi-organ complications of COVID-19. In this review, we will highlight the role of the complement system in the immunopathology of COVID-19, emphasizing the potential therapeutical targets to ameliorate COVID-19 infection.
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