2-微球蛋白在HIV感染中的诊断和预后意义。

G Cavalli, S Lopez, F Franzetti, M C Amprimo, P Ronchi, P Cinque, P Rivera, P C Gaido, A Lazzarin
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引用次数: 1

摘要

本文测定了80例获得性免疫缺陷综合征(AIDS)静脉吸毒成瘾者(IVDA)、128例伴持续性广泛性淋巴结病(PGL)的hiv阳性IVDA和44例hiv血清阴性IVDA的血清β 2-微球蛋白(beta 2-m)水平。80名艾滋病患者中有72名(90%)血清β 2-m水平升高,128名(82%)无艾滋病的艾滋病毒感染者中有105名(82%)血清β 2-m水平较高。hiv感染的PGL患者的平均β 2-m水平显著高于hiv阴性的IVDA患者。64例PGL患者中有9例(14%)在24-54个月内发展为艾滋病。在这些患者中,首次观察时储存的血清中β 2-m水平(5.16 +/- 2.37 mg/l)显著高于其他PGL患者(3.40 +/- 1.03 mg/l);特别是,β 2-m水平大于5.0 mg/l的7例PGL患者中有5例显示疾病进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic and prognostic significance of beta 2-microglobulin during HIV infection.

The serum levels of beta 2-microglobulin (beta 2-m) were determined in 80 intravenous drug addicts (IVDA) with acquired immunodeficiency syndrome (AIDS), in 128 HIV-positive IVDA with persistent generalized lymphadenopathy (PGL) and in 44 HIV-seronegative IVDA. Seventy-two out of 80 (90%) AIDS patients had elevated serum beta 2-m levels and high levels of beta 2-m were also found in 105 of 128 (82%) HIV-infected subjects without AIDS. The mean beta 2-m level was significantly higher in HIV-infected patients with PGL than in HIV-negative IVDA. Nine out of 64 (14%) PGL patients developed AIDS in a period of 24-54 months. In these patients the mean beta 2-m level (5.16 +/- 2.37 mg/l), obtained from sera stored at the first observation, was significantly higher than in the other PGL patients (3.40 +/- 1.03 mg/l); in particular, 5 out of 7 PGL patients with beta 2-m levels greater than 5.0 mg/l showed an advanced disease.

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