非小细胞肺癌患者血清叶酸受体-1水平的研究

Konuralp Tıp Dergisi Pub Date : 2022-10-06 DOI:10.18521/ktd.1165651

A. Çelikkol, E. Şeber, S. Güzel, A. Yolcu, T. Yetişyiğit, A. Yılmaz

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摘要

目的:叶酸受体-1 (FOLR1)在多种癌症细胞生长过程中参与叶酸转运的组织病理学过表达已被报道。血清FOLR1(sFOLR1)升高在上皮性卵巢癌中也有报道。目的是研究sFOLR1在非小细胞肺癌(NSCLC)患者中的水平以及针对叶酸代谢的标准化疗的反应预测。方法:在这项前瞻性研究中，研究了30名健康个体和60名4期恶性转移性NSCLC患者在标准化疗前后的sFOLR1水平。用于sFOLR1分析的商业免疫测定(ELISA)试剂盒。血清癌胚抗原(CEA)、维生素B12和叶酸水平也进行了研究。结果:在非小细胞肺癌患者中，sFOLR1水平显著升高(p

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Investigation of Serum Folate-Receptor-1 Levels in Patients with Non-Small Cell Lung Cancer

Objective: Histopathological overexpression of folate receptor-1 (FOLR1) involved in folate transport in cell growth has been reported in various cancers. Increased serum FOLR1(sFOLR1) has also been reported in epithelial ovarian cancer. The aim was to investigate sFOLR1 levels in non-small cell lung cancer (NSCLC) patients and the response prediction of the standard chemotherapy targeting folic acid metabolism. Method: In this prospective study, sFOLR1 levels were investigated in 30 healthy individuals and 60 patients with stage4 malign metastatic NSCLC before and after standard chemotherapy. The commercial immunoassay (ELISA) kit used for analysis of sFOLR1. Serum carcinoembryonic antigen (CEA), vitamin B12, and folate levels were also investigated. Result: In NSCLC patients sFOLR1 levels were significantly higher(p

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