O. A. Dina, A. Saba, A. Adedapo, O. Akinyemi, To Ombowale
{"title":"溴苄啶、醋酸迪米那烯及其联合用药对实验性感染刚果锥虫的新西兰大白兔的疗效比较研究。","authors":"O. A. Dina, A. Saba, A. Adedapo, O. Akinyemi, To Ombowale","doi":"10.4314/TV.V20I3.4495","DOIUrl":null,"url":null,"abstract":"Keywords: Trypanocides, Combination therapy, Haematology, Drug resistance \nComparative efficacy study of homidium bromide (Ethidium®), diminazene aceturate (Berenil®) and their combination (Ethidium®) was conducted on New Zealand while male rabbits experimentally infected with T. congolense. Parasitaemia was accompanied by significant depression of haematological parameters 28 days post-inoculation. While ethidium, berenil and their combination reduced trypanosomes to non-detectable levels in the blood. The average percentage restoration of haematological parameters to normal range 14 days post-treatment varied considerably; trypanocide combination (85%), ethidium (73%) and berenil (65%). The higher efficacy of trypanocide combination compared to single drug therapy and the usefulness of drug combination as a temporary measure to minimizing development of drug resistance is highlighted. \nTrop. Vet. Vol. 20(3) 2002: 153-158","PeriodicalId":428776,"journal":{"name":"Tropical veterinarian","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Comparative Efficacy Study of Homidium Bromde, Diminazene Aceturate and Their combination in New Zealand White Rabbits Experimentally Infected with Trypanosoma Congolense.\",\"authors\":\"O. A. Dina, A. Saba, A. Adedapo, O. Akinyemi, To Ombowale\",\"doi\":\"10.4314/TV.V20I3.4495\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Keywords: Trypanocides, Combination therapy, Haematology, Drug resistance \\nComparative efficacy study of homidium bromide (Ethidium®), diminazene aceturate (Berenil®) and their combination (Ethidium®) was conducted on New Zealand while male rabbits experimentally infected with T. congolense. Parasitaemia was accompanied by significant depression of haematological parameters 28 days post-inoculation. While ethidium, berenil and their combination reduced trypanosomes to non-detectable levels in the blood. The average percentage restoration of haematological parameters to normal range 14 days post-treatment varied considerably; trypanocide combination (85%), ethidium (73%) and berenil (65%). The higher efficacy of trypanocide combination compared to single drug therapy and the usefulness of drug combination as a temporary measure to minimizing development of drug resistance is highlighted. \\nTrop. Vet. Vol. 20(3) 2002: 153-158\",\"PeriodicalId\":428776,\"journal\":{\"name\":\"Tropical veterinarian\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tropical veterinarian\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/TV.V20I3.4495\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropical veterinarian","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/TV.V20I3.4495","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparative Efficacy Study of Homidium Bromde, Diminazene Aceturate and Their combination in New Zealand White Rabbits Experimentally Infected with Trypanosoma Congolense.
Keywords: Trypanocides, Combination therapy, Haematology, Drug resistance
Comparative efficacy study of homidium bromide (Ethidium®), diminazene aceturate (Berenil®) and their combination (Ethidium®) was conducted on New Zealand while male rabbits experimentally infected with T. congolense. Parasitaemia was accompanied by significant depression of haematological parameters 28 days post-inoculation. While ethidium, berenil and their combination reduced trypanosomes to non-detectable levels in the blood. The average percentage restoration of haematological parameters to normal range 14 days post-treatment varied considerably; trypanocide combination (85%), ethidium (73%) and berenil (65%). The higher efficacy of trypanocide combination compared to single drug therapy and the usefulness of drug combination as a temporary measure to minimizing development of drug resistance is highlighted.
Trop. Vet. Vol. 20(3) 2002: 153-158
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
