用知识图谱探索精神障碍的微生物-肠-脑轴

Ting Liu, Xueli Pan, Xu Wang, K. Feenstra, J. Heringa, Zhisheng Huang
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引用次数: 13

摘要

肠道微生物群通过肠脑轴的通讯途径对脑相关疾病有重要影响。Manyspeciesofgutmicrobiotaproduceavarietyofneurotransmitters。从本质上讲,神经递质是一种影响宿主情绪、认知和行为的化学物质。肠道菌群与神经递质之间的关系在医学和生物医学研究中受到广泛关注。然而,支持这些关系的各种提出的神经递质信号途径的整合尚未得到很好的研究。为了揭示肠道微生物群通过神经递质、微生物群-肠道-大脑(MGB)轴对心理健康的影响,我们将现有研究中的分散结果收集到一个结构化的知识库中。因此,在本文中,我们提出了一种新的微生物群知识图谱,以揭示肠道微生物群,神经递质和精神障碍之间的潜在关联,我们称之为MiKG。它包括许多连接到知名生物医学本体的接口,例如UMLS, MeSH, KEGG和SNOMED CT,并且可以通过连接到未来的本体来扩展,以进一步利用肠道微生物群和神经递质之间的关系。本文介绍了MiKG,一个有效的知识图谱,可用于研究MGB轴,使用肠道微生物群,神经递质和精神障碍之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Microbiota-Gut-Brain Axis for Mental Disorders with Knowledge Graphs
Gut microbiota has a significant influence on brain-related diseases through the communication routes of the gut-brain axis. Manyspeciesofgutmicrobiotaproduceavarietyofneurotransmitters.Inessence,theneurotransmittersarechemicalsthatinflu-ence mood, cognition, and behavior of the host. The relationships between gut microbiota and neurotransmitters has received much attention in medical and biomedical research. However, the integration of the various proposed neurotransmitter signal routes that underpin these relationships has not yet been studied well. To unlock the influence of gut microbiota on mental health via neurotransmitters, the microbiota-gut-brain (MGB) axis, we gather the decentralized results in the existing studies into a structured knowledge base. In this paper, we therefore propose a novel Microbiota Knowledge Graph based on a newly constructed knowledge graph for uncovering the potential associations among gut microbiota, neurotransmitters, and mental disorders which we refer to as MiKG. It includes many interfaces that link to well-known biomedical ontologies, e.g. UMLS, MeSH, KEGG, and SNOMED CT, and is extendable by linking to future ontologies to further exploit the relationships between gut microbiota and neurotransmitters. This paper present MiKG, an effective knowledge graph, that can be used to investigate the MGB axis using the relationships among gut microbiota, neurotransmitters, and mental disorders.
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