In Vivo Anticancer Activities of Vanillin Thiosemicarbazone Complexes with Co ( II ) and Ni ( II )

Sha M. S. Shahriar Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh. e-mail: shahan.acrubd@yahoo.com ABSTRACT The anticancer activities of vanillin thiosemicarbazone complexes with Co(II) and Ni(II) have been studied against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Both the complexes were administrated into the intraperitoneal cavity of the EAC-inoculated mice at two doses (5 and 7.5 mg/kg i.p.). The anticancer activities were studied by monitoring the parameters such as cell growth inhibition, tumor weight measurement, survival time of EAC-bearing mice, as well as the changes in depleted hematological parameters due to tumorigenesis. All data were compared with those of a known standard drug bleomycin at the dose of 0.3 mg/kg (i.p.). It has been found that these complexes significantly increased the life span of tumor-bearing mice and decreased the rate of growth and weight of tumor cells. They also restored modestly the depleted hematological parameters such as hemoglobin content, RBC count, and WBC count to normal. They enhanced the number of macrophages in normal mice with minor host toxicity. It is concluded that these compounds can be primarily considered as potent anticancer agents.