Anti-Histaminic Activity of Kaphaketu Rasa on Histamine Induced Bronchospasm in Guinea Pigs

Kaphaketu rasa is a classical herbo-mineral preparation used for Pratishyaya Kasa Shwasa and other respiratory disorders. It is a Khalveeya Rasayana judicially containing shodhita Vatsanabha Aconitum ferox Shodhita Tankana Borax Pippali Piper longum Shanka Bhasma Calyx of Conch amp Ardraka Swarasa Bhavana Juice of Ginger for 3 times. According to modern science Rhinitis Bronchitis Bronchial asthma are the similar conditions where in Kaphaketu Rasa is very effective clinically. Pathophysiologically histamine secretion and activity will be more in majority of the allergic disorders. Hematological examination reveals raised Absolute Esoinophilic Count.The formula is in clinical practice very effectively in aforesaid disorders. the claims of Ayurveda ought to be validated by suitable animal models with scientific parameters. Hence to get more documentary evidences updating of the knowledge and to get more scientifically confidence in Ayurvedic science the present study was carried out. Guinea pigs were fed with Kaphaketu rasa by oral route once a day for 5 days. The Kaphaketu Rasa showed statistically significant result at Plt0.001. Kaphaketu Rasa significantly extended the latent period of pre-convulsive Dyspnoea PCD as compared with control group.