生物计量学对染色体的自动分割和核型分析

D. Somasundaram, M. Nirmala
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引用次数: 3

摘要

染色体分析领域中最需要考虑的问题之一是染色体的分割和确定,着丝粒的检测和染色体的核合。以前依赖于着丝粒位置及其与p臂和q臂位置的夹角,键比较作为染色体的分类和染色体配对的可能性。因此,本文描述的可能性取决于田口实验设计技术,染色体中键之间的距离以及利用灰度图像的富集所做的检测点。它与最近文献中提出的类似研究也有一些独特和不同的特点。结果是基于这些客观和主观指标的结合来说明所提出的方法的定性性质及其对其性能的评价。实验结果表明,一种生物特征可以从另一种生物特征中确定。一条染色体与另一条染色体特征之间的比较,染色体配对时具有相同的特性。利用神经网络对每条染色体进行比较,最终实现染色体的核合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Automatic segmentation and karyotyping of chromosomes using bio-metrics
One of the most considerations in the field of chromosome analysis is the segmentation and determination of the centromere detection and karyotying of the chromosomes. Previously depend upon centromere position and its angle with the p-arm and q-arm positions, bond comparisons as made the classification of chromosomes and the pairing possibilities of the chromosomes. Such that in this paper as describe as the possibilities depend upon Taguchi experimental design technique, distance between the bonds in the chromosomes and the detection points made using the enrichment of the gray scaled image. It is also unique and different from similar studies recently presented in the literature with some superior features. The results were presented on the basis of the combination of these objective and subjective metrics for illustrating the qualitative properties of the proposed methods and its evaluation of their performances. Experimental results have shown that one biometric feature can be determined from another. The comparison between the feature from one chromosome with another, the same property of the chromosomes where paired. The process of comparison as done on each chromosome by the neural network and finally the karyotying of the chromosomes were achieved.
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