一种用于长期记录斑马鱼心外膜心电图的可穿戴经皮植入物

2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII) Pub Date : 2013-06-16 DOI:10.1109/TRANSDUCERS.2013.6626876

Yu Zhao, Fei Yu, H. Cao, Honglong Chang, Xiaoxiao Zhang, T. Hsiai, Y. Tai

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引用次数: 6

摘要

心脏作为人类再生能力最差的器官，即使在脑室截肢20%后，斑马鱼的心脏也能再生而不形成任何疤痕组织。从心脏周围多个固定位置记录的高空间分辨率心电图(ECG)可以阐明损伤组织和再生组织心脏电表型的变化。因此，设计、制作了一种可穿戴的斑马鱼经皮平面电极阵列束带，并将其放置在合适的位置，以揭示斑马鱼心脏再生过程中的电传导表型。记录电路和数据处理也进行了开发和定制，为未来水下无线长期实时心电记录铺平了道路。

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A wearable percutaneous implant for long term zebrafish epicardial ECG recording

Heart, as the least regenerative organ in human, can regenerate in zebrafish even after up to 20% ventricle amputation without forming any scar tissue. The Electrocardiogram (ECG) recorded from multiple fixed locations around the heart with high spatial resolution can elucidate changes in cardiac electric phenotypes of injured and regenerating tissues. Therefore, a wearable zebrafish harness with a percutaneous planar electrode array was designed, fabricated and properly positioned to uncover the electrical conduction phenotypes during the zebrafish heart regeneration. The recording circuitry and data processing have also been developed and customized, paving the way to the future underwater wireless long-term ECG recording in real time.

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2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)

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