{"title":"利多卡因治疗重型颅脑损伤的临床研究","authors":"向进, 王莉莉, 熊莉, 郭伟, 陈建良","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.02.006","DOIUrl":null,"url":null,"abstract":"目的 探讨应用利多卡因经静脉注射对重度颅脑外伤患者的治疗作用.方法重度颅脑外伤患者60例(GCS≤8分),随机分为两组,对照组30例,伤后予常规治疗;治疗组30例,伤后3d内予常规治疗加利多卡因静脉注射治疗14d.治疗前后均作GCS评分、腰穿测定颅内压、头部CT、ECT、TCD检查.结果治疗组利多卡因治疗2～5d即出现出现意识、肢体功能好转、脑血供改善、脑水肿吸收;10d后肢体功能明显恢复,脑血供和颅内血流速度接近正常,脑水肿消退,颅内压接近正常.对照组患者同期治疗后观察头部ECT、TCD、CT未见明显变化,意识、肢体功能、脑血供改善不明显、脑水肿消退缓慢.结论早期应用利多卡因静脉注射能缓解颅脑损伤患者脑血管痉挛,改善脑微循环,减轻脑缺血引起的脑水肿,使颅内压下降,促进脑功能恢复。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"36 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2006-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Study on Lidocaine in the Treatment of Severe Craniocerebral Injury\",\"authors\":\"向进, 王莉莉, 熊莉, 郭伟, 陈建良\",\"doi\":\"10.3760/CMA.J.ISSN.1008-634X.2006.02.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"目的 探讨应用利多卡因经静脉注射对重度颅脑外伤患者的治疗作用.方法重度颅脑外伤患者60例(GCS≤8分),随机分为两组,对照组30例,伤后予常规治疗;治疗组30例,伤后3d内予常规治疗加利多卡因静脉注射治疗14d.治疗前后均作GCS评分、腰穿测定颅内压、头部CT、ECT、TCD检查.结果治疗组利多卡因治疗2～5d即出现出现意识、肢体功能好转、脑血供改善、脑水肿吸收;10d后肢体功能明显恢复,脑血供和颅内血流速度接近正常,脑水肿消退,颅内压接近正常.对照组患者同期治疗后观察头部ECT、TCD、CT未见明显变化,意识、肢体功能、脑血供改善不明显、脑水肿消退缓慢.结论早期应用利多卡因静脉注射能缓解颅脑损伤患者脑血管痉挛,改善脑微循环,减轻脑缺血引起的脑水肿,使颅内压下降,促进脑功能恢复。\",\"PeriodicalId\":189947,\"journal\":{\"name\":\"Journal of Modern Clinical Medical Bioengineering\",\"volume\":\"36 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Modern Clinical Medical Bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.02.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Modern Clinical Medical Bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.02.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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