{"title":"[肺支原体感染对放线菌素D和环磷酰胺致畸作用的影响]。","authors":"N C Juhr, H Ratsch","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In the present investigation experiments have been made on the modification of the teratogenesis by a Mycoplasma pulmonis infection in rats. Substances with known teratogenic effects (Actinomycin D, Cyclophosphamide) were used. Groups of artificially infected pregnant rats were compared with pregnant rats from the SPF unit. The present study has shown that in the group of artificially infected animals no significant increase of the teratogenic effects by Actinomycin was found. In the Cyclophosphamide-treated groups more and more serious malformations have been observed in relation to dose and day of treatment.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 6","pages":"265-70"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Modification of the teratogenesis of actinomycin D and cyclophosphamide by a Mycoplasma pulmonis infection in rats].\",\"authors\":\"N C Juhr, H Ratsch\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In the present investigation experiments have been made on the modification of the teratogenesis by a Mycoplasma pulmonis infection in rats. Substances with known teratogenic effects (Actinomycin D, Cyclophosphamide) were used. Groups of artificially infected pregnant rats were compared with pregnant rats from the SPF unit. The present study has shown that in the group of artificially infected animals no significant increase of the teratogenic effects by Actinomycin was found. In the Cyclophosphamide-treated groups more and more serious malformations have been observed in relation to dose and day of treatment.</p>\",\"PeriodicalId\":76864,\"journal\":{\"name\":\"Zeitschrift fur Versuchstierkunde\",\"volume\":\"33 6\",\"pages\":\"265-70\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Versuchstierkunde\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Versuchstierkunde","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Modification of the teratogenesis of actinomycin D and cyclophosphamide by a Mycoplasma pulmonis infection in rats].
In the present investigation experiments have been made on the modification of the teratogenesis by a Mycoplasma pulmonis infection in rats. Substances with known teratogenic effects (Actinomycin D, Cyclophosphamide) were used. Groups of artificially infected pregnant rats were compared with pregnant rats from the SPF unit. The present study has shown that in the group of artificially infected animals no significant increase of the teratogenic effects by Actinomycin was found. In the Cyclophosphamide-treated groups more and more serious malformations have been observed in relation to dose and day of treatment.
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