非洲树乙醇叶提取物的毒性及镇静作用

A. Omotayo, Qudus A. Ojomo, S. Hassan, Mutolib Olatunbosun, M. Fakayode
{"title":"非洲树乙醇叶提取物的毒性及镇静作用","authors":"A. Omotayo, Qudus A. Ojomo, S. Hassan, Mutolib Olatunbosun, M. Fakayode","doi":"10.36108/pajols/9102/30(0160)","DOIUrl":null,"url":null,"abstract":"Background: Traditional plants have been good sources of alternatives for conventional drugs in recent years. The search for alternatives for conventional drugs becomes imperative most especially because of their high cost demand and side effects. The search for alternatives from traditional medicinal plants sources has been fruitful for many ailments and this has led to intense research on the potentials of many other plants that are used traditionally in different part of the world. This study assessed the sedative potentials of ethanol extract of Voacanga africana leaf (VAEE) as well as its toxicity.\nMethods: Toxicity of the Voacanga africana leaf was examined using Lorke’s method while its sedative activity was evaluated using phenobarbitone and ketamine-induced sleeping time models in mice. The doses used in this study were 50, 100, 200, 400 and 800 mg/kg, administered intra-peritoneal.\nResults: Results revealed that the LD50 of VAEE was greater than 5 g/kg. Using phenobarbitone-induced sedation, the sleep latency was found to be dose dependent and significantly decreased at higher dose when compared with normal saline while the total sleeping time was found to be significantly in-creased (p<0.05) as dosage increases.\nConclusion: The increase in total sleeping time using the two models showed that VAEE possesses marked sedative ability and can serve as a good alternative to conventional sedatives.","PeriodicalId":234626,"journal":{"name":"Pan African Journal of Life Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Toxicity and Sedative Effect of Voacanga Africana Ethanolic Leaf Extract\",\"authors\":\"A. Omotayo, Qudus A. Ojomo, S. Hassan, Mutolib Olatunbosun, M. Fakayode\",\"doi\":\"10.36108/pajols/9102/30(0160)\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Traditional plants have been good sources of alternatives for conventional drugs in recent years. The search for alternatives for conventional drugs becomes imperative most especially because of their high cost demand and side effects. The search for alternatives from traditional medicinal plants sources has been fruitful for many ailments and this has led to intense research on the potentials of many other plants that are used traditionally in different part of the world. This study assessed the sedative potentials of ethanol extract of Voacanga africana leaf (VAEE) as well as its toxicity.\\nMethods: Toxicity of the Voacanga africana leaf was examined using Lorke’s method while its sedative activity was evaluated using phenobarbitone and ketamine-induced sleeping time models in mice. The doses used in this study were 50, 100, 200, 400 and 800 mg/kg, administered intra-peritoneal.\\nResults: Results revealed that the LD50 of VAEE was greater than 5 g/kg. Using phenobarbitone-induced sedation, the sleep latency was found to be dose dependent and significantly decreased at higher dose when compared with normal saline while the total sleeping time was found to be significantly in-creased (p<0.05) as dosage increases.\\nConclusion: The increase in total sleeping time using the two models showed that VAEE possesses marked sedative ability and can serve as a good alternative to conventional sedatives.\",\"PeriodicalId\":234626,\"journal\":{\"name\":\"Pan African Journal of Life Sciences\",\"volume\":\"41 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pan African Journal of Life Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36108/pajols/9102/30(0160)\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pan African Journal of Life Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36108/pajols/9102/30(0160)","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

背景:近年来,传统植物已成为常规药物的良好替代品。寻找传统药物的替代品变得势在必行,尤其是因为它们的高成本需求和副作用。从传统药用植物中寻找替代品对许多疾病来说都是富有成效的,这导致了对世界不同地区传统使用的许多其他植物的潜力的密集研究。本研究考察了非洲木犀叶乙醇提取物(VAEE)的镇静作用及其毒性。方法:采用Lorke法检测非洲树叶的毒性,采用苯巴比妥和氯胺酮诱导小鼠睡眠时间模型评价其镇静作用。本研究使用的剂量分别为50、100、200、400和800 mg/kg,腹腔注射。结果:结果显示,VAEE的LD50大于5 g/kg。使用苯巴比妥诱导的镇静,睡眠潜伏期呈剂量依赖性,与生理盐水相比,高剂量时睡眠潜伏期明显减少,总睡眠时间随剂量增加而显著增加(p<0.05)。结论:两种模型的总睡眠时间均有明显的增加,表明VAEE具有明显的镇静作用,可作为常规镇静剂的良好替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicity and Sedative Effect of Voacanga Africana Ethanolic Leaf Extract
Background: Traditional plants have been good sources of alternatives for conventional drugs in recent years. The search for alternatives for conventional drugs becomes imperative most especially because of their high cost demand and side effects. The search for alternatives from traditional medicinal plants sources has been fruitful for many ailments and this has led to intense research on the potentials of many other plants that are used traditionally in different part of the world. This study assessed the sedative potentials of ethanol extract of Voacanga africana leaf (VAEE) as well as its toxicity. Methods: Toxicity of the Voacanga africana leaf was examined using Lorke’s method while its sedative activity was evaluated using phenobarbitone and ketamine-induced sleeping time models in mice. The doses used in this study were 50, 100, 200, 400 and 800 mg/kg, administered intra-peritoneal. Results: Results revealed that the LD50 of VAEE was greater than 5 g/kg. Using phenobarbitone-induced sedation, the sleep latency was found to be dose dependent and significantly decreased at higher dose when compared with normal saline while the total sleeping time was found to be significantly in-creased (p<0.05) as dosage increases. Conclusion: The increase in total sleeping time using the two models showed that VAEE possesses marked sedative ability and can serve as a good alternative to conventional sedatives.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信