哺乳动物角膜的比较化学形态。

Basic and applied histochemistry Pub Date : 1990-01-01
J E Scott, T R Bosworth
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引用次数: 0

摘要

一个简单的哺乳动物角膜基质模型已经在许多物种上进行了生化和超微结构测量。根据模型预测,水、胶原蛋白和总硫酸盐阴离子的含量是恒定的。阿利新蓝CEC结果显示物种间差异很大,CEC随角膜大小和厚度的增加而增加。这些变化是由于角蛋白硫酸盐含量的变化,特别是其过硫酸盐末端结构域,这在小鼠角膜中是不存在的。随着角膜厚度的增加,角蛋白硫酸盐含量的增加与薄角膜中皮肤硫酸盐的增加相平衡,因此在所有被调查的哺乳动物中,总硫酸盐GAG水平保持在恒定的“平均”水平。这种平衡可能是由氧张力决定的,氧张力会随着角膜厚度的变化而变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The comparative chemical morphology of the mammalian cornea.

A simple model of mammalian corneal stroma has been tested against biochemical and ultrastructural measurements performed on a number of species. Contents of water, collagen and total sulphated polyanion were constant, as predicted from the model. Alcian blue CEC results showed great variability between species, with a rise in CEC as corneal size and thickness increased. These variations were due to changes in keratan sulphate content, and particularly to its oversulphated terminal domain, which is absent from mouse cornea. The increase in keratan sulphate content with corneal thickness was balanced by an increase in dermatan sulphate in thin corneas, thus maintaining total sulphated GAG levels at a constant "average", in all the mammals investigated. This balance is probably decided by oxygen tension, which will vary with corneal thickness.

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