Clinical characteristics and treatment of primary ovarian malignant lymphoma

Objective: To investigate the clinical features and prognostic factors of primary ovarian lymphoma(POL). Methods: A retrospective review was performed based on the clinical records of 14 POL cases treated at Tianjin Medical University Oncology institute Hospital verity from 2000-6 to 2010-5. Results: The median age of patients was 47 years at presentation(range 28~62years). Abdominal pain was the most common initial symptom. The majority of histological subtype was B cell lymphoma, above 50% of which is diffuse large B-cell non-Hodgkin's lymphoma. A R0 resection was carried out in 2 patients who were lost to follow-up soon after surgery. 11 patients were treated by CHOP, FC or CHOPE chemotherapy. Chemotherapy combined with rituximab were given to 5 patients. Until now, 5 patients were alive, 6 patients died, and only one patient was lost to follow up after therapy. Conclusion: POL is an extremely rare lymphoma. The ultimate diagnosis depends on histopathologic examination. Primary ovarian non-Hodgkin lymphoma should be treated with multi-modality strategies. Treatment with doxorubicin-based chemotherapy after oophorotomy is recommended. B cell lymphoma preferred to use rituximab combination chemotherapy. Abdominal cavity chemotherapy prophylaxis and irradiation can decrease the probability for recurrence .