Haemostasis and biochemical parameters of liver function monitoring in the surgical treatment of portal hypertension

Bleeding varices are the complication of portal hypertension and an indication of surgical treatment. Investigation of biochemical parameters such as protein, albumin, cholesterol, billirubin, AST, ALT, as well as haemostasis parameters, including PT, APTT, TT, F II, F V, F VII, AT, plasminogen, could help define the effect of decompression shunt and its possible deleterious effect on the liver function. Investigation included 29 patients with portal hypertension, 19 surgically treated and 10 medication treated patients. F II, F V, F VII, AT, plasminogen and albumin concentration and PT (%) value were statistically significantly lower in medication treated patients in relation with surgically treated patients following one month observation. FVII expressed the highest sensitivity in all investigated parameters. Albumin and billirubin concentrations were in correlation with: PT, F II, F V, F VII and APTT, while transaminases were only in correlation with F VII. Surgical procedures had no effect on the synthetic function of the liver.