{"title":"胎儿生长受限孕妇血叶酸、维生素B12和同型半胱氨酸水平。","authors":"H. Jiang, L. Cao, H. Y. Chen","doi":"10.4238/gmr15048890","DOIUrl":null,"url":null,"abstract":"Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and categorized the neonates into the FGR, appropriate for gestational age, and large for gestational age groups. Birth weight, body length, head circumference, body mass index (BMI), and Rohrer's body index of the newborns were measured. Serum folic acid, vitamin B12, and homocysteine levels were measured in mothers during the first three days of their hospital stay. Results showed that the FGR group exhibited reduced folic acid and vitamin B12 levels and elevated homocysteine levels than those in the other two groups. Folic acid and vitamin B12 levels were positively correlated with birth weight, head circumference, and BMI, whereas homocysteine level was negatively correlated with these variables. The FGR ratio in the folic acid and vitamin B12 deficiency group was higher than that in the sufficiency group (χ2 = 4.717 and 4.437, P = 0.029 and 0.035, respectively). In addition, elevated homocysteine was associated with FGR (χ2 = 5.366, P = 0.021). In conclusion, we found that folic acid and vitamin B12 deficiency was associated with elevated homocysteine levels, which may increase susceptibility to FGR.","PeriodicalId":189314,"journal":{"name":"Genetics and molecular research : GMR","volume":"24 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction.\",\"authors\":\"H. Jiang, L. Cao, H. Y. Chen\",\"doi\":\"10.4238/gmr15048890\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and categorized the neonates into the FGR, appropriate for gestational age, and large for gestational age groups. Birth weight, body length, head circumference, body mass index (BMI), and Rohrer's body index of the newborns were measured. Serum folic acid, vitamin B12, and homocysteine levels were measured in mothers during the first three days of their hospital stay. Results showed that the FGR group exhibited reduced folic acid and vitamin B12 levels and elevated homocysteine levels than those in the other two groups. Folic acid and vitamin B12 levels were positively correlated with birth weight, head circumference, and BMI, whereas homocysteine level was negatively correlated with these variables. The FGR ratio in the folic acid and vitamin B12 deficiency group was higher than that in the sufficiency group (χ2 = 4.717 and 4.437, P = 0.029 and 0.035, respectively). In addition, elevated homocysteine was associated with FGR (χ2 = 5.366, P = 0.021). In conclusion, we found that folic acid and vitamin B12 deficiency was associated with elevated homocysteine levels, which may increase susceptibility to FGR.\",\"PeriodicalId\":189314,\"journal\":{\"name\":\"Genetics and molecular research : GMR\",\"volume\":\"24 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genetics and molecular research : GMR\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4238/gmr15048890\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetics and molecular research : GMR","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4238/gmr15048890","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
摘要
叶酸和维生素B12等营养物质的缺乏可能在胎儿生长受限(FGR)中发挥作用。然而,叶酸、维生素B12或同型半胱氨酸是否与中国人群的FGR有关尚不清楚。本研究探讨了这些营养缺乏与中国孕妇FGR之间的关系。我们选取116对母婴,将新生儿分为胎龄适宜组和胎龄较大组。测定新生儿出生体重、体长、头围、体重指数(BMI)、罗氏体指数。在母亲住院的前三天,测量了她们的血清叶酸、维生素B12和同型半胱氨酸水平。结果表明,与其他两组相比,FGR组叶酸和维生素B12水平降低,同型半胱氨酸水平升高。叶酸和维生素B12水平与出生体重、头围和BMI呈正相关,而同型半胱氨酸水平与这些变量呈负相关。叶酸和维生素B12缺乏组的FGR高于维生素B12充足组(χ2 = 4.717、4.437,P = 0.029、0.035)。同型半胱氨酸升高与FGR相关(χ2 = 5.366, P = 0.021)。总之,我们发现叶酸和维生素B12缺乏与同型半胱氨酸水平升高有关,这可能会增加对FGR的易感性。
Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction.
Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and categorized the neonates into the FGR, appropriate for gestational age, and large for gestational age groups. Birth weight, body length, head circumference, body mass index (BMI), and Rohrer's body index of the newborns were measured. Serum folic acid, vitamin B12, and homocysteine levels were measured in mothers during the first three days of their hospital stay. Results showed that the FGR group exhibited reduced folic acid and vitamin B12 levels and elevated homocysteine levels than those in the other two groups. Folic acid and vitamin B12 levels were positively correlated with birth weight, head circumference, and BMI, whereas homocysteine level was negatively correlated with these variables. The FGR ratio in the folic acid and vitamin B12 deficiency group was higher than that in the sufficiency group (χ2 = 4.717 and 4.437, P = 0.029 and 0.035, respectively). In addition, elevated homocysteine was associated with FGR (χ2 = 5.366, P = 0.021). In conclusion, we found that folic acid and vitamin B12 deficiency was associated with elevated homocysteine levels, which may increase susceptibility to FGR.