面部剂型产品的配方和生理稳定性,它含有非洲叶提取物的Carbopol浓度的变化

Dwi Rachmawaty Daswi, Arisanty Arisanty, St Mutmainnah Dewi Reski, Alfrida Monica Salasa, St. Ratnah
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引用次数: 0

摘要

非洲叶子(Vernonia amygdalina Del.)是一种天然抗氧化剂,因为它含有酚类化合物,包括类黄酮,可以抵御自由基。本研究旨在以非洲叶提取物为原料制备面部凝胶制剂,以确定制剂物理质量的稳定性。非洲树叶是用浸渍法提取的,然后用三种不同的配方配制成一种面部凝胶。三种不同卡泊酚浓度的凝胶配方分别为0.5%、1%、2%。在加速稳定性试验(冻融)前后对面部凝胶制剂进行物理质量测试,包括感官测试、均匀性测试、协同作用测试、pH值测试、散射功率测试和粘度测试。结果表明,除pH值测试外,1%卡泊泊浓度的配方II几乎满足加速稳定性试验前后物理质量测试的所有要求,0.5%卡泊泊泊泊和2%卡泊泊泊的配方I仅满足均质性、协同性和粘度测试要求。统计检验结果显示P> 0.05,即加速存储前后的测试结果无显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulasi Dan Stabilitas Mutu Fisik Sediaan Gel Wajah Yang Mengandung Ekstrak Daun Afrika Dengan Variasi Konsentrasi Carbopol
African leaves (Vernonia amygdalina Del.) are plants that have benefits as natural antioxidants because it contain phenolic compounds including flavonoids that can wardoff free radicals. This study aims to formulate facial gel preparations from African leaf extracts to determine the stability of the physical quality of the preparations. African leaves are extracted using the maceratio method and then formulated into a facial gel made in three variations of the formula. Three gel formulas made with different carbopol concentrations are 0.5%, 1%, 2%. Physical quality testing of facial gel preparations is performed before and after the accelerated stability test (freeze thaw), including organoleptics, homogeneity tests, syneresis tests, pH tests, scatterpower tests and viscosity tests. Based on the results, formula II with 1 % carbopol concentration fulfilled almost all the requirement of the physical quality test carried out before and after the accelerated stability test excep for pH testing, for formula I with 0,5 % carbopol concentration and formula III with 2 % carbopol concentration only met homogenity,synerisis and viscosity test requirement.The result of statistical test showed the result of P>0,05 which means there is no significant difference from the test results before and after accelerateds storage.
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