{"title":"生长激素对雌雄大鼠妊娠相关蛋白-1 (PAMP-1)分泌的影响。","authors":"J Hau, P H Jørgensen, O M Poulsen, B Bak","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of 2 daily injections of human growth hormone (hGH) on serum levels of pregnancy-associated murine protein-1 (PAMP-1) was analysed in male and female Mol:WIST rats. In untreated control male rats the PAMP-1 level in the circulation is below the detection limit of rocket immunoelectrophoresis whereas females have a high serum level of PAMP-1. hGH treatment of male rats resulted in a dose-dependent increase in PAMP-1 concentration, whereas a similar treatment of female rats resulted in a significant decrease of the PAMP-1 concentration in serum. Methylprednisolone treatment either alone or in combination with hGH had no significant effect on the level of PAMP-1 in serum of male rats. It is concluded that the normal sexually determined different secretion pattern of PAMP-1 can be modified towards an intermediate pattern by administration of exogenous hGH.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 6","pages":"277-82"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of growth hormone on secretion of pregnancy-associated murine protein-1 (PAMP-1) in female and male rats.\",\"authors\":\"J Hau, P H Jørgensen, O M Poulsen, B Bak\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of 2 daily injections of human growth hormone (hGH) on serum levels of pregnancy-associated murine protein-1 (PAMP-1) was analysed in male and female Mol:WIST rats. In untreated control male rats the PAMP-1 level in the circulation is below the detection limit of rocket immunoelectrophoresis whereas females have a high serum level of PAMP-1. hGH treatment of male rats resulted in a dose-dependent increase in PAMP-1 concentration, whereas a similar treatment of female rats resulted in a significant decrease of the PAMP-1 concentration in serum. Methylprednisolone treatment either alone or in combination with hGH had no significant effect on the level of PAMP-1 in serum of male rats. It is concluded that the normal sexually determined different secretion pattern of PAMP-1 can be modified towards an intermediate pattern by administration of exogenous hGH.</p>\",\"PeriodicalId\":76864,\"journal\":{\"name\":\"Zeitschrift fur Versuchstierkunde\",\"volume\":\"33 6\",\"pages\":\"277-82\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Versuchstierkunde\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Versuchstierkunde","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of growth hormone on secretion of pregnancy-associated murine protein-1 (PAMP-1) in female and male rats.
The effect of 2 daily injections of human growth hormone (hGH) on serum levels of pregnancy-associated murine protein-1 (PAMP-1) was analysed in male and female Mol:WIST rats. In untreated control male rats the PAMP-1 level in the circulation is below the detection limit of rocket immunoelectrophoresis whereas females have a high serum level of PAMP-1. hGH treatment of male rats resulted in a dose-dependent increase in PAMP-1 concentration, whereas a similar treatment of female rats resulted in a significant decrease of the PAMP-1 concentration in serum. Methylprednisolone treatment either alone or in combination with hGH had no significant effect on the level of PAMP-1 in serum of male rats. It is concluded that the normal sexually determined different secretion pattern of PAMP-1 can be modified towards an intermediate pattern by administration of exogenous hGH.
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