Spiral artery remodeling in pregnancy

Brosen et al. suggested that the “physiological change” of spiral arteries in the pregnant uteri was a result of the destructive action of invading trophoblast on vascular smooth muscles and elastic membranes [5]. Later, a maternal contribution had to be considered since some changes in the maternal vessel wall precede the antidromic migration of trophoblast along the vessel lumen. Some researchers believe that the local intravasation of interstitial trophoblast is more likely [6].