直肠直肠癌患者放化疗期间外周血中性粒细胞功能活性改变的可能性

E. Slepov, R. Zukov, M. S. Serbaeva, A. Karapetyan, O. Kashaeva, A. Pavlenko, Y. Kozina
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摘要

背景。电离辐射是一种有效的抗肿瘤治疗方法,但它对免疫系统有严重的负面影响,需要使用辐射反应预防和减少方法。中性粒细胞是免疫系统中与肿瘤组织相互作用和对辐射损伤反应的敏感元素。目的:用化学发光法评价肛肠癌放疗后患者外周血中性粒细胞的功能活性。材料和方法。该研究包括80名患有肛门直肠癌的患者。患者接受化疗和放疗,包括三维适形放疗和视觉控制下的放疗,随后分别使用和不使用放射保护剂。化学发光法测定中性粒细胞活性。在肛肠癌患者中发现最大的自发和诱导化学发光加速。肛门直肠癌患者鲁米诺的化学发光激活指数较低,而lucigenin的化学发光激活指数与对照组无差异。较低的发光强度,以及酶系统中活性氧合成的减少,可能是细胞内调节限制的结果。治疗后,radioprotector组患者的各项参数数量与对照组相比均有所下降,差异有统计学意义。在肛肠癌患者放疗及后续观察期间未发现脱氧核糖核酸钠治疗相关不良现象。在治疗期间,化学发光参数的差异表明电离辐射对接受标准放化疗的肛肠癌患者的影响。使用放射保护剂的放化疗可间接恢复细胞功能活性。药物治疗开始后,鲁米诺依赖性化学发光更快达到最大值,显著差异数较对照组减少,证实了这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Possibility of modification of peripheral blood neutrophils functional activity during chemoradiotherapy in patients with anorectal cancer
Background. Ionizing radiation is an effective antitumor therapy, but it has a serious negative effect on the immune system requiring the use of radiation reaction prevention and reduction methods. Neutrophils are a sensitive element of the immune system both in interaction with tumor tissue and in response to radiation injury.Aim. To evaluate functional activity of peripheral blood neutrophils by chemiluminescent analysis in patients with anorectal cancer after radiotherapy.Materials and methods. The study included 80 patients with anorectal cancer. Patients received chemo- and radio-therapy with 3D conformal radiotherapy and radiation therapy under visual control, followed by the use of radioprotector and without it. Neutrophil activity determined by chemiluminescent analysis.Results. In patients with anorectal cancer found maximum spontaneous and induced chemiluminescence acceleration. The chemiluminescence activation index with luminol is lower in patients with anorectal cancer, and with lucigenin shows no differences with the control group. The low luminol chemiluminescence maximum intensity, as well as the decrease in the synthesis of reactive secondary oxygen species in enzymatic systems, is likely regulatory intracellular limitations consequence. After treatment, patients with radioprotector showed a decrease in the number of parameters with statistically significant differences with the control group. Undesirable phenomena associated with sodium deoxyribonucleate therapy not detected in anorectal cancer patients during radiotherapy and subsequent observation period.Conclusion. During treatment, differences in chemiluminescence parameters suggest that ionizing radiation affects them in patients with anorectal cancer receiving standard chemoradiotherapy. Use of chemoradiotherapy with a radioprotector leads to indirect restoration of cellular functional activity. This is confirmed by luminol-dependent chemiluminescence faster reaching its maximum and a decrease in the number of significant differences from the control group after the start of the drug treatment.
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