Long term clinical outcome of dental implants placed in a patient with aggressive periodontitis and Glucose-6-phosphate dehydrogenase (G6pd) deficiency

Background and objectives

Aggressive Periodontitis is associated with higher risk of periimplantitis and lower implant survival. Glucose-6-phosphate dehydrogenase (G6pd) deficiency is an enzymatic disorder which may produce hemolytic anemia in red blood cells. Since G6pd helps to maintain intracellular redox potential, a deficiency produces a weak interface at the marginal gingiva and additionally a reduced wound healing due to hemolysis. This case report discusses the clinical features and treatment protocol used to achieve osseointegration of dental implants in grafted and non grafted regions in a patient having aggressive periodontitis, congenital G6pd deficiency, refractory to conventional periodontal therapy.

Methods

Following extraction of the remaining teeth, 10 titanium implants (Straumann AG) were placed, starting with 4 implants in the mandible. After 5 years, augmentation of the extremely atrophic maxilla was performed. On one side the augmentation failed, however a total of 6 implants could be placed in the maxilla. The patient was followed up regularly for 15 years.

Results

The long term follow up (9 years in the maxilla and 15 years in the mandible) of the inserted implants showed 100% success rate.

Conclusion

Rehabilitation with dental implants in patients having aggressive periodontitis is a reasonable treatment option to restore maxillo-mandibular function and esthetics.