2018年保加利亚西尼罗河神经侵入性疾病的数量出乎意料地高

I. Christova, E. Panayotova, I. Trifonova, E. Taseva, T. Gladnishka
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引用次数: 1

摘要

西尼罗病毒(WNV)是近年来在欧美广泛传播的一种新型虫媒病毒。本研究分析了2018年保加利亚可能和确诊的西尼罗河病毒人间病例的流行病学数据和实验室结果。2018年共发现15例西尼罗河病毒感染患者,其中2例死亡。所有患者均于8月或9月确诊。4例患者来自索非亚区,4例来自布尔加斯区,3例来自普罗夫迪夫区,舒曼区、扬博尔区和帕扎尔日克区各1例。7例患者的实验室诊断仅基于血清样本中特异性抗体的检测。8例患者符合西尼罗河病毒确诊病例标准。其中6例患者血液或尿液中检测到西尼罗河病毒基因组,3例患者脑脊液中检测到特异性IgM抗体,证实西尼罗河病毒神经侵袭性感染。保加利亚2018年确诊的西尼罗河病毒人间病例数量众多,这是人们对该疾病认识不断提高的一个好迹象。在进行病毒基因组基因检测的临床样本的适当运输方面需要更多的努力。应怀疑西尼罗河病毒神经侵入性感染,并将其纳入病毒性脑炎或脑膜脑炎的鉴别诊断,特别是在夏末秋初。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
UNEXPECTEDLY HIGH NUMBER OF WEST NILE NEUROINVASIVE DISEASES IN BULGARIA IN 2018
West Nile virus (WNV) is an emerging arbovirus in Europe and America which disseminated widely in recent years. This study analysed epidemiological data and laboratory findings of probable and confirmed human WNV cases in Bulgaria in 2018. A total of 15 patients with WNVinfection were detected in 2018, with 2 deaths among them. All patients were diagnosed in August or September. Four patients were from Sofia district, 4 from Burgas, 3 from Plovdiv and 1 from each of the following districts: Shumen, Yambol and Pazardzhik. Laboratory diagnosis for 7 of the patients was based solely on detection of specific antibodies in the serum samples. Eight patients met the criteria for confirmed WNV case. In 6 of them WNV genome was detected by RT-PCR in blood or urine sample and in 3 patients specific IgM antibodies were found in CSF samples which confirmed WNV neuroinvasive infection. The high number of diagnosed human WNV cases in 2018 in Bulgaria is a good sign of increasing recognition of the disease. More efforts are needed in proper transportation of clinical samples undergoing genetic detection of the viral genome. WNV neuroinvasive infection should be suspected and included in the differential diagnosis of viral encephalitis or meningoencephalitis especially in late summer and early autumn.
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