纳米药物设计策略及其在癌症治疗中的靶向应用

Umar Noor, T. Ahmed, Saliha Khalid, Maryam Khalid, Ammara Sharif, Isra Noor, Warda Waheed, Ishmal Jamil, Zainab Sameen Zafar, U. Kulsum
{"title":"纳米药物设计策略及其在癌症治疗中的靶向应用","authors":"Umar Noor, T. Ahmed, Saliha Khalid, Maryam Khalid, Ammara Sharif, Isra Noor, Warda Waheed, Ishmal Jamil, Zainab Sameen Zafar, U. Kulsum","doi":"10.56536/ijpihs.v4i1.68","DOIUrl":null,"url":null,"abstract":"Introduction: Recent medical improvements have not much of an influence on cancer patients' life expectancy throughout the world. Nano medicine is a cutting-edge topic in cancer therapy, with various well-tested techniques for delivering drugs. Objectives: Liposomes and other nanostructures are often used in therapeutic contexts and scientists in numerous countries are currently investigating polymer micelles. These structures will become more lucrative if they include chemicals that help with site-specific delivery and tailored release. The objective of the current review is to provide comprehensive information on nano-drugs. Methods: Liposomes, polymer micelles, and dendrites, among other well-known nanoparticle technologies, can be controlled and regulated to generate a more long-lasting and effective non-therapeutic modality. Occasionally, the term \"multistage drug delivery\" is used. This method, which employs a well-designed Nano-carrier, overcomes several biological barriers to medicine delivery. Results: Several multistage drug delivery system papers were reviewed for this study and their advantages were discussed with some pharmaceutical drug examples as well. Conclusions: We emphasize developments in nanoparticle design that overcome heterogeneous delivery barriers and contend that intelligent nanoparticle design can boost effectiveness in general delivery applications especially cancer treatment while enabling customized designs for precision applications, ultimately improving patient outcomes.","PeriodicalId":142550,"journal":{"name":"International Journal of Pharmacy & Integrated Health Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NANO-DRUG DESIGNING STRATEGIES AND TARGETED APPLICATIONS FOR CANCER TREATMENT\",\"authors\":\"Umar Noor, T. Ahmed, Saliha Khalid, Maryam Khalid, Ammara Sharif, Isra Noor, Warda Waheed, Ishmal Jamil, Zainab Sameen Zafar, U. Kulsum\",\"doi\":\"10.56536/ijpihs.v4i1.68\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Recent medical improvements have not much of an influence on cancer patients' life expectancy throughout the world. Nano medicine is a cutting-edge topic in cancer therapy, with various well-tested techniques for delivering drugs. Objectives: Liposomes and other nanostructures are often used in therapeutic contexts and scientists in numerous countries are currently investigating polymer micelles. These structures will become more lucrative if they include chemicals that help with site-specific delivery and tailored release. The objective of the current review is to provide comprehensive information on nano-drugs. Methods: Liposomes, polymer micelles, and dendrites, among other well-known nanoparticle technologies, can be controlled and regulated to generate a more long-lasting and effective non-therapeutic modality. Occasionally, the term \\\"multistage drug delivery\\\" is used. This method, which employs a well-designed Nano-carrier, overcomes several biological barriers to medicine delivery. Results: Several multistage drug delivery system papers were reviewed for this study and their advantages were discussed with some pharmaceutical drug examples as well. Conclusions: We emphasize developments in nanoparticle design that overcome heterogeneous delivery barriers and contend that intelligent nanoparticle design can boost effectiveness in general delivery applications especially cancer treatment while enabling customized designs for precision applications, ultimately improving patient outcomes.\",\"PeriodicalId\":142550,\"journal\":{\"name\":\"International Journal of Pharmacy & Integrated Health Sciences\",\"volume\":\"10 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pharmacy & Integrated Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56536/ijpihs.v4i1.68\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmacy & Integrated Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56536/ijpihs.v4i1.68","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

导言:最近的医学进步对全世界癌症患者的预期寿命没有太大影响。纳米医学是癌症治疗的一个前沿课题,具有各种经过良好测试的药物输送技术。目的:脂质体和其他纳米结构经常用于治疗环境,许多国家的科学家目前正在研究聚合物胶束。如果这些结构包含有助于特定地点输送和定制释放的化学物质,它们将变得更加有利可图。本综述的目的是提供纳米药物的综合信息。方法:脂质体、聚合物胶束和树突,以及其他众所周知的纳米颗粒技术,可以控制和调节,以产生更持久和有效的非治疗方式。有时也使用“多级给药”这个术语。这种方法采用了一种精心设计的纳米载体,克服了药物传递的几个生物障碍。结果:对多阶段给药系统的相关文献进行了综述,并结合一些药物实例对其优点进行了讨论。结论:我们强调纳米颗粒设计的发展,克服异质递送障碍,并认为智能纳米颗粒设计可以提高一般递送应用的有效性,特别是癌症治疗,同时实现精确应用的定制设计,最终改善患者的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NANO-DRUG DESIGNING STRATEGIES AND TARGETED APPLICATIONS FOR CANCER TREATMENT
Introduction: Recent medical improvements have not much of an influence on cancer patients' life expectancy throughout the world. Nano medicine is a cutting-edge topic in cancer therapy, with various well-tested techniques for delivering drugs. Objectives: Liposomes and other nanostructures are often used in therapeutic contexts and scientists in numerous countries are currently investigating polymer micelles. These structures will become more lucrative if they include chemicals that help with site-specific delivery and tailored release. The objective of the current review is to provide comprehensive information on nano-drugs. Methods: Liposomes, polymer micelles, and dendrites, among other well-known nanoparticle technologies, can be controlled and regulated to generate a more long-lasting and effective non-therapeutic modality. Occasionally, the term "multistage drug delivery" is used. This method, which employs a well-designed Nano-carrier, overcomes several biological barriers to medicine delivery. Results: Several multistage drug delivery system papers were reviewed for this study and their advantages were discussed with some pharmaceutical drug examples as well. Conclusions: We emphasize developments in nanoparticle design that overcome heterogeneous delivery barriers and contend that intelligent nanoparticle design can boost effectiveness in general delivery applications especially cancer treatment while enabling customized designs for precision applications, ultimately improving patient outcomes.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信