THE ROLE OF ANTIDEPRESSANTS IN THE CORRECTION OF CLINICAL, ENDOCRINE AND NEUROTRANSMITTER DISORDERS IN SUICIDAL BEHAVIOR: THE SEARCH FOR NEW THERAPEUTIC TRAJECTORIES

Abstract. In order to study issues related to the drug correction of clinical, endocrine and neurotransmitter disorders in persons with suicidal behavior, the study of medical statistics of the neuropsychiatric service for the period from 2005 to 2022 was conducted. The paper highlights the ways to identify people with suicidal behavior, studied the prerequisites for its development. All studies were conducted in accordance with Article 11 of the Law of the Russian Federation of 02.07.1992 N 3185-1 (edition of 30.12.2021) "On psychiatric care and guarantees of the rights of citizens in its provision". The difference between true and false suicide has been determined. Pathogenetic mechanisms of formation of endocrine and neurotransmitter disorders, methods of treatment and prevention of suicidal mood are considered. Gender and age characteristics, as well as issues related to suicide in various countries of the world are analyzed. The cause-and-effect relationships that can lead to the act of suicide are highlighted. It was revealed that demographic mortality rates as a result of completed suicides were higher in the regions of the republic than in cities and amounted to 18.1- 24.5 per one hundred thousand population, the greatest suicide risk was observed at the age of 17 to 30 years. Many patients in this group either did not seek medical help from a psychiatrist at all due to stigmatization, or there was no compliance in treatment. These individuals independently stopped taking antidepressants after 1-2 weeks from the start of taking these drugs with the appearance of a slight initial improvement. The role of COVID-19 and its impact on the human psyche, as well as the role of the virus in the development of suicidal behavior, is touched upon. It was revealed that in the blood and cerebrospinal fluid in patients with suicidal behavior, there is an imbalance of cytokine status in the form of a decrease in the level of IL-10, an increase in the concentration of S-IL-2R, IL-1, IL-2, IL-6; a decrease in the activity and function of natural T cells. We have analyzed static data and made conclusions on this problem.