A study of comparison of duration of intrathecal bupivacaine plus midazolam vs bupivaine alone for postoperatively analgesia in the patients of caesarean delivery

Background: "Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Inadequate pain control, apart from being inhumane, may result in increased morbidity or mortality. Aims and Objectives: To Study comparison of efficacy of intrathecal bupivacaine plus midazolam vs bupivaine alone for postoperatively analgesia in the patients of caesarean delivery. Methodology: The present study was carried out during period of January 2009 to September 2009. sixty patients of age group 18-40 years were selected for the presented study. Patients undergoing caesarean section as SA grade I and II and not having fetal distress selected for study. Preoperative evaluation of all patients was done. Group A : (n=30) received Inj.Bupivacaine 0.5% heavy 2 ml (10 mg) , Group B : (n=30) received Inj.Bupivacaine 0.5% heavy 2 ml (10 mg) + inj.Midazolam 0.5% , 0.2 ml (1mg) .Pain was accessed by duration of analgesia and VAS-score at 1 hr and 3 hr. The statistical analysis was done by Chi –square test, unpaired t-test calculated by SPSS 19 version software. Results : In our study we have seen that The mean age in group A and Group B was 23.8 ± 3.47 Yrs. and 24±4 comparable (t=0.207,p>0.05).The duration of anesthesia was more in Group B i.e. 88.66± 17.75 as compared to 86±16.15 but the difference was not statistically significant (t=0.608,p>0.05) . The duration of analgesia was more in Group B i.e. 246±39 as compared to 200 ±21 but the difference was not statistically significant (t=0.608,p>0.05) .The doses required for analgesia was less in group A i.e. 2.93±0.630 vs in Group B i.e. 2.96±0.490 but the difference was not statistically significant (t=0.226,p>0.05) .The most of the patients with VAS 2 or 3 were more in Group A as compared to Group B but the difference was not significant (X2 =1.950,p>0.05). The most of the patients with VAS 6,4, 3 or 2 were more in Group A as compared to Group B but the difference was not significant (X2 =2.70 ,p>0.05) Conclusion : It can be concluded from our study that addition of the midazolam improved the duration of analgesia, less VAS score but not significantly differed hence for the definite conclusion further studies with large samples are needed.