ii型审查下Gumbel ii型分布的贝叶斯估计及其医学应用

Kamran Abbas, Z. Hussain, Noreen Rashid, Amjad Ali, M. Taj, S. Khan, Sadaf Manzoor, U. Khalil, Dost Muhammad Khan
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引用次数: 21

摘要

发生事件的时间或生存时间通常遵循一定的偏概率分布。这些分布在使用贝叶斯框架分析和预测最大预期寿命方面发挥着至关重要的作用,以便为决策提供信息。贝叶斯方法为监测随机临床试验提供了一个灵活的框架,利用不确定情况下特定现象的先验信息来更新已知的内容。此外,医疗从业者可以使用贝叶斯估计量通过考虑先验信息来测量HIV患者到肿瘤复发的时间概率、到心血管死亡的时间概率和到艾滋病的时间概率。然而,在临床试验和医学研究中,当不知道确切的事件发生时间时,就会进行审查。本研究旨在利用贝叶斯框架估计基于ii型截尾数据的Gumbel ii型分布的参数。贝叶斯估计量不能以显式形式得到,因此我们使用基于非信息先验和各种损失函数(如平方误差损失函数、一般熵损失函数和LINEX(线性指数)损失函数)的Lindley近似。通过仿真研究,比较了极大似然估计和贝叶斯估计的均方误差。此外,为了说明目的,我们分析了61例不能手术的肺腺癌患者的缓解时间(以月为单位)和生存时间(以周为单位)的两个数据集。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bayesian Estimation of Gumbel Type-II Distribution under Type-II Censoring with Medical Applications
The time to event or survival time usually follows certain skewed probability distributions. These distributions encounter vital role using the Bayesian framework to analyze and project the maximum life expectancy in order to inform decision-making. The Bayesian method provides a flexible framework for monitoring the randomized clinical trials to update what is already known using prior information about specific phenomena under uncertainty. Additionally, medical practitioners can use the Bayesian estimators to measure the probability of time until tumor recurrence, time until cardiovascular death, and time until AIDS for HIV patients by considering the prior information. However, in clinical trials and medical studies, censoring is present when an exact event occurrence time is not known. The present study aims to estimate the parameters of Gumbel type-II distribution based on the type-II censored data using the Bayesian framework. The Bayesian estimators cannot be obtained in explicit forms, and therefore we use Lindley’s approximation based on noninformative prior and various loss functions such as squared error loss function, general entropy loss function, and LINEX (linear exponential) loss function. The maximum likelihood and Bayesian estimators are compared in terms of mean squared error by using the simulation study. Furthermore, two data sets about remission times (in months) of bladder cancer patients and survival times in weeks of 61 patients with inoperable adenocarcinoma of the lung are analyzed for illustration purposes.
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