Sadiq Al-Mansury, Suhad J. Hadi, Nabah H. Checkor, Mohammed J. Jawad, Hussein A. Ghanimi, Adnan M. Jassim, Hawraa T. Abass, Rusul Heider, Hamzah H. Kzar, Moaed E. Al-Gazally
{"title":"芳基丙酸新衍生物对胃雄性小鼠的镇痛作用评价","authors":"Sadiq Al-Mansury, Suhad J. Hadi, Nabah H. Checkor, Mohammed J. Jawad, Hussein A. Ghanimi, Adnan M. Jassim, Hawraa T. Abass, Rusul Heider, Hamzah H. Kzar, Moaed E. Al-Gazally","doi":"10.21931/rb/css/2023.08.01.17","DOIUrl":null,"url":null,"abstract":"This study focused on the recent synthesis of new compounds from aryl propionic acid derivatives compared to naproxen. The present study aimed to investigate\nthe safety and efficiency of the new derivatives in improving analgesic effects\nand reducing adverse effects via modifying its chemical structure by adding new\nfunctional groups. The new compounds were characterized, and evaluate their\npharmacodynamic effects. The analysis and characterization of new compounds\nwere by 1HMNR and FT-IR spectrum. The investigation of the adverse effect after 5 days of remedy with 20 mg/kg daily administered with naproxen derivatives\nto the healthy male albino mice (25-30 g) for analgesic activity using the hot\nplate method. Mice were parted into 5 groups, consisting of the control group and\n4 groups that administered naproxen or derivatives of aryl propionic acid (E, H,\nD1 and D2). The main tests are done by a hot plate, biochemical, macroscopic,\nand microscopic inspection. The results confirmed that the new drugs have potent\nanalgesic activity. The results showed that mice administered with D1 expressed\nless ulcerative effect than parent naproxen, H, E and ethanol. Moreover, the\nnumber of lesions was significantly less in the D2 group, while D1-treated mice\nrecorded no evidence of ulcers or hemorrhage in their stomachs after being examined under a dissecting microscope. The study concluded that the new D1 derivative is a compound worthy of research and future clinical applications due to its\nrelatively high efficacy and low adverse effects compared to other derivatives\nprepared and tested in this study.\nKeywords: Analgesic, Aryl propionic acid, Naproxen, Acidity","PeriodicalId":443152,"journal":{"name":"Sumer 1","volume":"5 4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the analgesic activity of new derivatives of aryl propionic acid on gastric\\nmale mice\",\"authors\":\"Sadiq Al-Mansury, Suhad J. Hadi, Nabah H. Checkor, Mohammed J. Jawad, Hussein A. Ghanimi, Adnan M. Jassim, Hawraa T. Abass, Rusul Heider, Hamzah H. Kzar, Moaed E. Al-Gazally\",\"doi\":\"10.21931/rb/css/2023.08.01.17\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study focused on the recent synthesis of new compounds from aryl propionic acid derivatives compared to naproxen. The present study aimed to investigate\\nthe safety and efficiency of the new derivatives in improving analgesic effects\\nand reducing adverse effects via modifying its chemical structure by adding new\\nfunctional groups. The new compounds were characterized, and evaluate their\\npharmacodynamic effects. The analysis and characterization of new compounds\\nwere by 1HMNR and FT-IR spectrum. The investigation of the adverse effect after 5 days of remedy with 20 mg/kg daily administered with naproxen derivatives\\nto the healthy male albino mice (25-30 g) for analgesic activity using the hot\\nplate method. Mice were parted into 5 groups, consisting of the control group and\\n4 groups that administered naproxen or derivatives of aryl propionic acid (E, H,\\nD1 and D2). The main tests are done by a hot plate, biochemical, macroscopic,\\nand microscopic inspection. The results confirmed that the new drugs have potent\\nanalgesic activity. The results showed that mice administered with D1 expressed\\nless ulcerative effect than parent naproxen, H, E and ethanol. Moreover, the\\nnumber of lesions was significantly less in the D2 group, while D1-treated mice\\nrecorded no evidence of ulcers or hemorrhage in their stomachs after being examined under a dissecting microscope. The study concluded that the new D1 derivative is a compound worthy of research and future clinical applications due to its\\nrelatively high efficacy and low adverse effects compared to other derivatives\\nprepared and tested in this study.\\nKeywords: Analgesic, Aryl propionic acid, Naproxen, Acidity\",\"PeriodicalId\":443152,\"journal\":{\"name\":\"Sumer 1\",\"volume\":\"5 4 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sumer 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21931/rb/css/2023.08.01.17\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sumer 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21931/rb/css/2023.08.01.17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of the analgesic activity of new derivatives of aryl propionic acid on gastric
male mice
This study focused on the recent synthesis of new compounds from aryl propionic acid derivatives compared to naproxen. The present study aimed to investigate
the safety and efficiency of the new derivatives in improving analgesic effects
and reducing adverse effects via modifying its chemical structure by adding new
functional groups. The new compounds were characterized, and evaluate their
pharmacodynamic effects. The analysis and characterization of new compounds
were by 1HMNR and FT-IR spectrum. The investigation of the adverse effect after 5 days of remedy with 20 mg/kg daily administered with naproxen derivatives
to the healthy male albino mice (25-30 g) for analgesic activity using the hot
plate method. Mice were parted into 5 groups, consisting of the control group and
4 groups that administered naproxen or derivatives of aryl propionic acid (E, H,
D1 and D2). The main tests are done by a hot plate, biochemical, macroscopic,
and microscopic inspection. The results confirmed that the new drugs have potent
analgesic activity. The results showed that mice administered with D1 expressed
less ulcerative effect than parent naproxen, H, E and ethanol. Moreover, the
number of lesions was significantly less in the D2 group, while D1-treated mice
recorded no evidence of ulcers or hemorrhage in their stomachs after being examined under a dissecting microscope. The study concluded that the new D1 derivative is a compound worthy of research and future clinical applications due to its
relatively high efficacy and low adverse effects compared to other derivatives
prepared and tested in this study.
Keywords: Analgesic, Aryl propionic acid, Naproxen, Acidity