敌敌畏乳腺癌危险性的关键评价

Renu Gandhi, S. Snedeker
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引用次数: 5

摘要

摘要敌敌畏曾经是一种非常流行和常用的有机磷农药。敌敌畏的应用并不局限于农业。它被广泛用作公共场所和家庭的杀虫剂。它的许多不同的非农业应用创造了广泛接触的可能性。敌敌畏的使用受到限制,因为担心其可能致癌。在本报告中,我们对国际癌症研究机构(IARC)的方法进行了修改,对暴露于敌敌畏导致癌症风险的任何直接或相关证据进行了详细评估,重点是乳腺癌风险。我们严格评估了所有现有的人类、实验动物和与癌症相关的敌敌畏分子和机制研究。包括化学和最新的监管信息,以及对敌敌畏的环境命运和人类接触的可能性的讨论。我们把敌敌畏归为第三类。在乳腺癌和环境风险因素项目(BCERF)的乳腺癌风险分类方案(见附录B)中,这一组代表了不能归类为人类乳腺癌风险的化学物质。然而,对实验动物的研究提供了足够的证据表明,接触敌敌畏会增加其他部位的癌症风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Critical Evaluation of Dichlorvos’ Breast Cancer Risk
Abstract Dichlorvos was once a very popular and commonly used organophosphate pesticide. Dichlorvos applications were not restricted to agriculture. It was widely used as an insecticide in public places and in homes. Its many different non-agricultural applications created the potential for widespread exposure. Dichlorvos use was restricted in response to concerns about its cancer causing potential. For this report, we have used a modification of the International Agency for Research on Cancer (IARC) approach to conduct a detailed evaluation of any direct or related evidence of cancer risk from exposure to dichlorvos, with a focus on breast cancer risk. We have critically evaluated al I the available human, experimental animal, and cancer-related molecular and mechanistic studies on dichlorvos. Chemical and up-to-date regulatory information is included, as well as a discussion of dichlorvos’ environmental fate and potential for human exposure. We have classified dichlorvos in Group 3. In the Program on Breast Cancer and Environmental Risk Factor's (BCERF) breast cancer risk classification scheme (see Appendix B), this group represents chemicals that are not classifiable for breast cancer risk in humans. However, studies in experimental animals provide enough evidence to suggest that dichlorvos exposure can increase cancer risk at other sites.
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