The Effect of Aerobic Training with Vitamin C Supplementation on Myeloperoxidase, Asymmetric Dimethyl Arginine and Blood Pressure in Middle-Age Hypertensive Overweight Men

Background: Cardiovascular diseases such as hypertension are global health concerns. Objectives: The purpose of this study was the effect of intensive aerobic training with vitamin C supplementation on myeloperoxidase (MPO), asymmetric dimethyl arginine (ADMA), and blood pressure (BP) in hypertensive men. Methods: Fortyhypertensivemen(age: 44.6 ± 3.5y,bodymassindex: 28.2 ± 1.2kg.m -2 )volunteeredtoparticipateinthisstudyand wererandomlydividedintofourgroupsof aerobictrainingwithvitaminC(ATV;N=10),aerobictrainingwithplacebo(ATP;N=10), vitamin C group (VC; N = 10) and control (Con; N = 10). The exercise training consisted of running training, which was done three timesaweekfor10weeks,withtheintensityof 75% -85% HRmax,andthedurationof 20-45minutes. ATPandVCgroupsconsumed daily500mgof vitaminCorplacebo. Fastingbloodsamplesweremeasuredbeforethestarttrainingprotocoland24hourafterlast training sessions to measure MPO and ADMA in the serum. Results: TheresultsofpresentstudyshowedthatADMAandBPweresignificantlydecreasedonlyinATVandATP(P ≤ 0.05). However, MPO did not change significantly (P > 0.05). Also, were seen that no significant difference between ATV and ATP groups (P > 0.05). Conclusions: It can be concluded that, aerobic training caused to decrease of dimethyl arginine, that can be a good strategy for control or decrease of blood pressure in hypertensive subjects, however intensive aerobic training with vitamin C may have better efficacy.