The role of neutrofiles and by macrophages in the pathogenesis of inflammatory and I post inflammatory episodes : Major tissue damage may be inflicted by a synergy among their toxic pro inflammatory agents

In his manuscript we summarize the role played by the variety of pro inflammatory agents generated by neutrofiles and by macrophages and how these cells may act in synergy to injure human and tissues in various inflammatory and in post inflammatory conditions. Screening the vast published literature, we found that most of papers published on inflammation, tend to stress only the role played by a very few pro inflammatory agents as key agents in inflammation. This is unreasonable to try to understand how leukocytes kill microbial cells and injure mammalian cells in various medical conditions. This is since the PMNs and macrophages produce numerous inflammatory agents.