口腔鳞状细胞癌患者颈部淋巴结转移与神经周围浸润的关系

PJMD 12-3 Pub Date : 2023-07-01 DOI:10.36283/pjmd12-3/003
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引用次数: 0

摘要

背景:宫颈淋巴结转移(CLNM)是口腔鳞状细胞癌的关键预后因素之一,阳性神经周围浸润(PNI)是宫颈淋巴结转移、复发和无衰退生存的预测因子。本研究确定了口腔鳞状细胞癌(OCSCC)的神经周围浸润与颈部淋巴结转移的关系。方法:对卡拉奇某三级医院外科病理档案中收集的实验室资料进行分析。本回顾性研究纳入了2008年6月至2019年3月10年间所有接受颈部淋巴结清扫的确诊OCSCC病例。这些病例的特征根据年龄、性别、神经周围浸润和淋巴结转移。采用SPSS统计软件对数据进行分析,采用卡方检验分析颈淋巴结转移与PNI状态的关系。结果:共发现527例经诊断的OCSCC伴颈夹层。从我们的研究中可以看出,OCSCC合并颈部解剖标本常见于男性,主要属于中年成人年龄组,其次是青壮年。527例患者中,PNI 165例(31.3%),其中20%的PNI患者颈淋巴结转移阳性,40%为良性颈淋巴结,PNI阴性。结论:本研究强调了PNI的单一参数及其与颈淋巴结转移的相关性,并显示神经周围浸润与颈淋巴结转移状态有显著关系(p < 0.001)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Cervical Lymph Node Metastasis and Perineural Invasion in Patients with Oral Cavity Squamous Cell Carcinoma
Background: Cervical lymph node metastasis (CLNM) is one of the key prognostic factors in oral squamous cell carcinoma and positive perineural invasion (PNI) is a predictor of cervical lymph node metastasis, recurrence, and decline-free survival. This study determines perineural invasion association with cervical lymph node metastasis in oral cavity squamous cell carcinoma (OCSCC). Method: We analyzed the laboratory data collected from the surgical pathology files of a tertiary care hospital in Karachi. This retrospective study included all diagnosed cases of OCSCC that underwent cervical lymph node dissection during the 10-year period from June 2008 to March 2019. The cases were characterized according to age, gender, perineural invasion, and lymph node metastasis. The data was analyzed using SPSS and Chi-Square test was used to find the association between the cervical lymph node metastatic and PNI status. Results: A total of 527 diagnosed cases of OCSCC with cervical neck dissection were found. It is evident from our study that OCSCC with neck dissection specimens is frequently seen in males, mostly belonging to the middle adult age group followed by young adults. Of the 527 cases, 165 showed PNI (31.3%), and 20% of the PNI cases were positive for cervical lymph node metastasis, while 40% showed benign cervical lymph nodes with negative PNI. Conclusion: This study highlights the single parameter of PNI and its association with cervical lymph node metastasis and showed a significant relationship between perineural invasion and cervical lymph node metastatic status (p < .001).
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