DRUG UTILIZATION EVALUATION OF MACROLIDES IN ENT OUTPATIENT DEPARTMENT IN TEACHING HOSPITAL PUNJAB, PAKISTAN.

Background: A major danger to the health care system is the rise in antibiotic resistance. The aim of current Study is to evaluate the comparison defined daily dose (DDD) and prescribed daily dose (PDD) of macrolide and to evaluate the prescribing pattern of the drug, either it met the standards or not. Methodology: Quantitative, retrospective study was carried out to measure the use of antibiotics specifically macrolide antibiotics in ENT outdoor department of teaching hospital Punjab, Pakistan. Study research from August 2021 to October 2021, the patient who was reported in OPD of ENT department during study period of 3 month retrospectively. Results: Total 438 prescriptions were collected and reviewed to evaluate the prescribing pattern of macrolides in outdoor patients of ENT department. Out of 438 prescriptions only in one prescription 10 antibiotics was prescribe (polypharmacy) and in 19(4.3%) prescriptions only one antibiotic is prescribed. Drug prescribed by their generic were 438(100). Encounter with antibiotics 95%. All drug were prescribed from essential drug list (EDL). Azithromycin was the most commonly prescribed drug in ENT department, followed by clarithromycin. Conclusion: Control bacterial resistance is become challenge to our health care system, major portion of our population is become resistance to majority classes of antibiotic if this practice will continue in future, it became difficult to control or treat infectious diseases. Irrational use of drugs, over prescribing of antibiotics and brand prescribing were observing during the study. Lack of knowledge and non-adherence to the prescribing indicators are the major factors that contribute towards the irrational drug prescribing that ultimately leads towards the antibiotics resistance.