表观遗传药物-癌症治疗的未来

Annals of Experimental and Molecular Biology Pub Date : 1900-01-01 DOI:10.23880/aemb-16000106

Deepanwita Sengupta

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摘要

表观遗传学是指在不影响潜在DNA序列的情况下发生的基因表达的任何改变。表观遗传机制通过在组蛋白上添加或去除乙酰基或/和甲基来促进核小体重排，从而调节染色质对转录因子的可及性。核小体是染色体的基本单位，由147个碱基对的DNA包裹在组蛋白的八聚体上

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Epigenetic Drugs - The Future of Cancer Therapy

Epigenetics refers to any alteration in gene expression that occurs without affecting the underlying DNA sequence. Epigenetic mechanisms regulate the accessibility of chromatin to transcription factors by promoting nucleosomal rearrangement via the addition or removal of acetyl or/and methyl groups to histones. Nucleosomes are basic units of chromosomes comprising of 147 base pairs of DNA wrapped around an octamer of histone proteins

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Annals of Experimental and Molecular Biology

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