Level of Vitamin D3 in Women who have Uterine Fibroids

Background: Uterine fibroid are the most common benign pelvic tumors among women in reproductive age group that has multifactorial pathogenesis. Vitamin D has become one of the key elements of modern theories of uterine fibroid pathogenesis. Aim: This work aim to investigate the association between vitamin D3 status and uterine leiomyoma. Materials and Methods: This observational case control study was conducted on 150 women in their reproductive age (20-45 years) at Ain-Shams University Hospital in the department of Obstetrics and Gynecology from March 2019 till August 2019. They were divided into two groups. 75 women with at least one uterine fibroid detected by transvaginal ultrasound to be considered as case group and the other 75 women with normal uterine examination and transvaginal ultrasound representing the control group. Results: In the current study, there was a statistically significant difference between cases group and control group as regard 25(OH) D level (P=0.001), the mean vitamin D level in the case group was 13.39±7.93 ng/ml and in the control group was 21.71±8.95 ng/ml. There was no statistical significant difference between the size of fibroid and vitamin D level. The mean serum vitamin D level in patients with small fibroid (size less than 5 cm) was 14.11ng/ml and 12.76 ng/ml for women with large fibroid (size more than 5 cm) (P=0.457). Conclusion: There is a significant association between vitamin D deficiency in reproductive age women and uterine fibroid. There is no correlation between vitamin D level and the size of uterine fibroid.