口腔聚合物的生物相容性及其在口腔环境中的反应

N. Stavreva, B. Kapusevska
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引用次数: 1

摘要

牙科聚合物,通常被称为“牙科树脂”,于1839年首次用于牙科,从那时起,它们已成为牙科修复、美容和功能目的的有利候选者。在过去的三十年里,许多由聚合物制成的假体和植入物已经被使用,人们一直在寻找更具生物相容性和更强的聚合物假体材料。聚合物在牙科中的典型应用是印模材料、衬材材料、临时冠材料、义齿基托材料、封闭材料(牙髓治疗)和填充材料(复合材料、水泥、粘合剂)。用于口腔的牙科聚合物应该对所有口腔组织-牙龈,粘膜,牙髓和骨骼无害。此外,它不应含有有毒的、可浸出的或可扩散的物质,这些物质可以被吸收到循环系统中,引起全身毒性反应,包括致畸或致癌作用。这些材料也不应含有可引起致敏或致敏病人过敏反应的药剂。很少,牙科聚合物的意外副作用可能会由于毒性,刺激性或过敏反应而发生。在口腔修复学中应用最广泛的聚合物是聚甲基丙烯酸甲酯树脂(PMMA),它用于制造各种义齿和义齿衬套、临时冠和正畸器具。本论文的目的是提供一个概述目前文献对牙科聚合物的毒理学,并给出可能的影响,以改善其生物相容性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BIOCOMPATIBILITY AND REACTION OF DENTAL POLYMERS IN ORAL ENVIRONMENT
Dental polymers, commonly known as “Dental Resins” were first used in dentistry in 1839, and since then they have emerged as a favorable candidate for restorative dentistry and cosmetic and functional purposes. Many prosthesis and implants made from polymers have been in use for the last three decades and there is a continuous search for more biocompatible and stronger polymer prosthetic materials. Typical applications of polymers in dentistry are impression materials, relining materials, temporary crown materials, denture base materials, obturation materials (endodontic treatment), and filling materials (composite, cements, adhesives). The dental polymers that are to be used in the oral cavity should be harmless to all oral tissues – gingiva, mucosa, pulp, and bone. Furthermore, it should contain no toxic, leachable, or diffusible substance that can be absorbed into the circulatory system, causing systemic toxic responses, including teratogenic or carcinogenic effects. The materials should also be free of agents that could elicit sensitization or an allergic response in a sensitized patient. Rarely, unintended side effects of dental polymers may occur as a result of toxic, irritative, or allergic reactions. The most widely used polymer in prosthodontics is polymethyl-methacrylate resin (PMMA), which is used for fabrication of various dental prostheses and denture liners, temporary crowns and orthodontic appliances. The aim of the current paper is to provide an overview of the current literature on toxicology of dental polymers and to give implications for possible improvements concerning their biocompatibility.
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