镍钛诺在脊柱植入物制造中的特点

M. Parsafar, S. Sadrnezhaad, N. Hassanzadeh Nemati
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摘要

由于与脊柱相关的疾病越来越多,我们期望在这一领域看到更多关于植入物的研究。这些植入物应该具有强度、抗疲劳性、化学稳定性和生物相容性等特征,幸运的是,这些特征都存在于一种叫做镍钛诺的合金中。本研究采用镍钛诺制备了6个腰椎植入物,并通过x射线衍射和生物相容性(MTT法评价细胞毒性)等实验对其进行了研究。最后,我们得出结论,上述合金具有合适的显微组织,适合医疗应用,特别是作为骨科植入物。x射线衍射图表明,室温下样品具有奥氏体结构,多孔样品的主要相为B2-NiTi。由于样品在体内放置后应具有生物相容性,不应引起免疫系统反应,因此也对该试验进行了检查,并用MTT试剂盒对样品进行了体外测试,并评估了生物相容性。生物相容性测试的结果也表明了植入物在细胞特性方面的适用性。这些特性使该合金在骨科植入物的应用中优于其他合金,特别是在连续载荷下的区域。希望这种类型的植入物的构建将为促进脊柱异常的治疗铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Characteristics of Nitinol in Spinal Implant Manufacturing
: Due to the increasing number of diseases related to the spine, we expect to see more research on the implants used in this area. These implants should have features such as strength, fatigue resistance, chemical stability and biocompatibility, which fortunately are seen in an alloy called nitinol. In this study, six lumbar vertebral implants were made of nitinol and these samples been studied by some experiments such as: X-ray diffraction and biocompatibility (evaluation of cytotoxicity by MTT assay). Finally, we came to the conclusion that the mentioned alloy with suitable microstructure is appropriate for medical applications specially as an orthopedic implant. According to the X-ray diffraction pattern, the samples have austenitic structures in the room temperature and the predominant phase of the porous sample is B2-NiTi. Since the sample should be biocompatible after placement in the body and should not cause an immune system reaction, this test was also examined and the samples were tested in vitro with an MTT kit and the biocompatibility was assessed. The results of biocompatibility tests also indicate the suitability of the implant in terms of cellular characteristics. These properties have made this alloy superior to other alloys in orthopedic implant utilization, especially in areas under continuous loading. It is hoped that the construction of this type of implant will pave the way for facilitating the treatment of spinal abnormalities.
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