Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao
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引用次数: 0
摘要
我们研究了肿瘤患者放疗所致贫血的Hepcidin (HEP)、Erythropoietin (EPO)、Albumin (ALB)和Prealbumin (PA)的表达特点及发病机制。我们检测了446例接受放疗的肿瘤患者的血红蛋白(HB)浓度，并测定了92例患者的血清HEP、EPO、ALB和PA，探讨放疗所致贫血的发病机制。结果:(1)446例患者放疗前后HB水平分别为119.85±19.87g/L和116.32±24.25g/L (t=2.5211, P < 0.05)。(7)放疗前后ALB与HB呈正相关(P<0.01)。(8)放疗前后PA与HB呈正相关(均P<0.01)。因此，放疗可引起癌症患者贫血，使其营养状况恶化。贫血负反馈抑制HEP的表达，而EPO具有高度代偿性。
Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO
We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, P 0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all P<0.01). (8) There were positive correlation between PA and HB before and after radiotherapy (all P<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.
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