导管胰腺腺癌免疫组织化学及形态学特征的新资料

Y. Y. Rakina, M. V. Zav’yalova, N. V. Krakhmal, A. Koshel, S. Afanasyev, S. Vtorushin, S. Klokov
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摘要

近年来,特别是在发达国家,胰腺癌的发病率有所上升。只有20%的肿瘤在诊断时被评估为可切除的,但在这些病例中,疾病的预后是不利的。总体5年生存率不超过5%。胰腺癌在18世纪60年代由乔瓦尼·巴蒂斯塔·莫加尼在他的经典著作《De Sedibus et Causis Morborum per Anatomen Indigatis》中描述。在接下来的200年里,病理学家显著提高了我们对这种疾病的宏观和微观特征的理解。同时,形态学研究几个世纪以来一直是诊断学的基础。在20世纪70年代末和80年代初,将免疫组织化学研究引入临床实践,从根本上改变了我们诊断这种疾病的方法。形态学特征的评价,以及决定此类肿瘤侵袭潜力的标志物的表达特征,可以作为未来解决此类定位恶性肿瘤预后可能因素问题的基本依据。研究目的:探讨胰腺导管腺癌的形态学和免疫组织化学特征。材料和方法。本研究纳入84例胰腺癌T1-4N0-2M0-1期患者,年龄37 ~ 83岁,均行手术治疗。对操作材料进行了形态学研究。纳入研究的条件是肿瘤的组织型,即导管胰腺腺癌。根据标准程序进行材料张贴、组织制剂制备、着色、免疫组织化学检查。结果与结论。该研究使肿瘤形态的表征以及与肿瘤侵袭性特征更明显相关的标志物的表达特征成为可能。这项工作的结果可能是感兴趣的,就他们的进一步比较参数的各种形式的进展胰腺癌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New data on the immunohistochemical and morphological characteristics of ductal pancreatic adenocarcinoma
In recent years, especially in developed countries, there has been an increase in the incidence of pancreatic cancer. Only 20% of tumors at the time of diagnosis are evaluated as resectable, but in these cases, the prognosis of the disease is unfavorable. The overall 5-year survival rate does not exceed 5%. Pancreatic cancer was described in the 1760s by Giovanni Battista Morgagni in his classic book “De Sedibus et Causis Morborum per Anatomen Indigatis”. Over the next 200 years, pathologists significantly improved our understanding of the macro- and microscopic features of this disease. At the same time, morphological research remained the basis of diagnostics for centuries. The introduction of immunohistochemical studies into clinical practice in the late 1970s and early 1980s radically changed our approach to diagnosing this disease. Evaluation of morphological features, as well as features of expression of markers that determine the invasive potential of such neoplasms, can serve in the future as a fundamental basis in solving questions concerning possible factors of prognosis upon malignant tumors of such a localization. Aim of research — to study the morphological and immunohistochemical features of ductal pancreatic adenocarcinoma. Materials and methods. The study included 84 patients with pancreatic cancer T1-4N0-2M0-1 stage, aged from 37 to 83, who underwent surgical treatment. Morphological study of the operating material was carried out. The condition for inclusion in the study was a histotype of the tumor, namely ductal pancreatic adenocarcinoma. Posting of the material, preparation of histological preparations, coloring, immunohistochemical examination were carried out according to a standard procedure. Results and conclusion. The study made it possible to characterize the tumor morphology, as well as the features of expression of markers associated with more evident invasive characteristics of the tumor. The results of this work may be of interest in terms of their further comparison with the parameters of various forms of progression upon pancreatic cancer.
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