The Effectiveness of Kersen Leaf Extracts (Muntingia calabura L.) on Cutting Wounds Infected with Sthapylococcus Aureus Bacteria

One of the plants that has been used by the community is cherry (Muntingia calabura L.) which is a lush plant, easy to breed, often on the side of the road, allowed to grow as a shade tree. Traditionally used to treat bleeding wounds, festering and burns, inflammation of the walls of blood vessels accompanied by blood clots in their channels. Fresh or dried cherry leaves are used as a medicine for wounds by finely grinding them and placing them on the wound. The use of cherry leaves directly in the treatment of wounds is not liked by the community, so they tried to formulate it in the form of cream preparations. Based on this, the researchers conducted a phytochemical screening and formulation of cherry leaf extract in cream preparations as well as tested its effectiveness for treating wounds. Extraction was carried out by percolation using 80% ethanol. Phytochemical screening was carried out on fresh leaves, simplicia, and ethanol extract of cherry leaves. And formulated into cream preparations with concentrations of 2.5%, 5% and 7.5%. The effectiveness for wound healing was carried out on artificial incisions on the back skin of male guinea pigs infected with Staphylococcus aureus bacteria. Measured decrease in wound diameter and observation of the width of the pus and the amount of edema. The results of the phytochemical screening test showed that there were the same groups of chemical compounds in fresh leaves, simplicia, and ethanol extract of cherry leaves, namely alkaloids, flavonoids, tannins, triterpenoids/steroids. The greater the concentration of EEDK in the cream, the faster the wound will heal. On the 16th day, 5% EEDK; 7.5%; and gentamicin provide 100% perfect wound healing. Means that the ethanol extract of cherry leaves at a concentration of 5% has a very good ability to heal incisions infected with Staphylococcs aureus.