胎盘TLR-7表达与脐血HBV DNA及胎盘HBV DNA的关系

Naeny Fajriah, M. Chalid, Lenny Lisal, E. Lukas, St. Nur Asni, R. Masadah
{"title":"胎盘TLR-7表达与脐血HBV DNA及胎盘HBV DNA的关系","authors":"Naeny Fajriah, M. Chalid, Lenny Lisal, E. Lukas, St. Nur Asni, R. Masadah","doi":"10.24198/obgynia.v4n2.289","DOIUrl":null,"url":null,"abstract":"Abstract Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Method: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Result: 16 of 38 samples were acquired from mothers aged 26-30 years old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p=1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p=0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p=0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. Key word: toll-like receptor (TLR) 7, HBV DNA, umbilical cord, placental, Hepatitis B, intrauterine infection","PeriodicalId":210732,"journal":{"name":"Indonesian Journal of Obstetrics & Gynecology Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship of Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA\",\"authors\":\"Naeny Fajriah, M. Chalid, Lenny Lisal, E. Lukas, St. Nur Asni, R. Masadah\",\"doi\":\"10.24198/obgynia.v4n2.289\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Method: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Result: 16 of 38 samples were acquired from mothers aged 26-30 years old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p=1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p=0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p=0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. Key word: toll-like receptor (TLR) 7, HBV DNA, umbilical cord, placental, Hepatitis B, intrauterine infection\",\"PeriodicalId\":210732,\"journal\":{\"name\":\"Indonesian Journal of Obstetrics & Gynecology Science\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indonesian Journal of Obstetrics & Gynecology Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24198/obgynia.v4n2.289\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indonesian Journal of Obstetrics & Gynecology Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24198/obgynia.v4n2.289","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

摘要目的:通过检测母婴血清乙型肝炎标志物,探讨TLR-7表达在妊娠期宫内垂直传播中的作用。方法:采用TLR免疫组化染色法对38例HBV感染母亲胎盘组织石蜡块进行TLR表达分析。结果:38份样本中有16份来自26-30岁的母亲。其中以初产妇居多(52.6%)。本研究发现胎盘和脐带血中TLR-7表达与HBV DNA无显著相关性(p=1.000)。然而,我们发现胎盘TLR-7表达与母体HBV DNA显著相关(p=0.034)。同时,胎盘HBeAg和HBV DNA与胎盘TLR-7表达无相关性(p=0.082;P = 1.000)。结论:胎盘和脐带血中TLR-7表达与HBV DNA无显著相关性,但我们发现TLR-7表达与母体HBV DNA有显著相关性。关键词:toll样受体(TLR) 7, HBV DNA,脐带,胎盘,乙型肝炎,宫内感染
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship of Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA
Abstract Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Method: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Result: 16 of 38 samples were acquired from mothers aged 26-30 years old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p=1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p=0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p=0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. Key word: toll-like receptor (TLR) 7, HBV DNA, umbilical cord, placental, Hepatitis B, intrauterine infection
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信