Soft Sensors for Biomass Monitoring during Low Cost Cellulase Production

Low cost cellulase production has become a major challenge in recent years. The major hurdle in the production of biofuel and other products from biomass is the lack of efficient economically feasible cellulase. This can be achieved by proper monitoring and control of bioprocess. In order to implement any control scheme, the accurate representation of the system in the form of a model is necessary. There are many challenges associated with modeling the fermentation process such as inherent nonlinear dynamic behavior, complexity of process due to co-existence of viable and nonviable cells, presence of solid substrates, etc. Toward the achievement of this goal, researchers have been developing new techniques that can be used to monitor the process online and at-line. These newer techniques have paved the way for designing better control strategies that can be integrated with quality by design (QbD) and process analytic technology (PAT).