Synthesis and Biological Screening of Novel Derivatives of Benzothiazol as Anticonvulsant Agents

The Benzothiazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of benzothiazole and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of bezothiazole obtained from 3-chloro-4-flouro aniline treated with potassium thiocynide with chloro acetyl chloride gives (7-chloro-6-fluro-1,3-benzothiazol-2-yl) acetyl chloride which is converted into hydrazide and yields the resultant compound derivatives of 2-(7-chloro-6-fluro-1,3-benzothiazol-2-yl) –N’-[(Z)-phenyl methylidene] acetohydrazide (SMVB-IIIA-IIIG).Title compound were synthesized and the structures of newly synthesized compounds were confirmed by IR, Mass and 1H-NMR spectroscopy All the compounds synthesized were confirmed by spectral data and evaluated for their anticonvulsant activity. The Compounds SMVB-IIIC, SMVB-IIIEand SMVB-IIIF showed maximal activity whereas remaining compounds showed good activity.