SAR Journal of Medical Biochemistry最新文献

{"title":"Recent Advances in the Treatment of Coronary Artery Disease","authors":"Anil Batta","doi":"10.36346/sarjmb.2024.v05i02.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2024.v05i02.001","url":null,"abstract":"In the last decade, significant advancements in CAD treatment have been made. The existing treatment is medical, surgical, or a combination of both depending on the extent, severity, and clinical presentation of CAD. The collaboration between different science disciplines such as biotechnology and tissue engineering has led to the development of novel therapeutic strategies such as stem cells, nanotechnology, robotic surgery, and other advancements (3-D printing and drugs). These treatment modalities show promising effects in managing CAD and associated conditions. Research on stem cells focuses on studying the potential for cardiac regeneration, while nanotechnology research investigates nano-drug delivery and percutaneous coronary interventions including stent modifications and coatings.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140267169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginger and Onion: Pakistani Herbs to be used in Treating Hyperlipidemia and Oxidative Stress","authors":"S. Zafar, Ali Abuzar Raza, M. Iqbal, Z. H. Tanveer, Syed Zeeshan Hyder Naqvi, Afsheen Mushtaq Shah, Farzana Majeed, Shaher Murad","doi":"10.36346/sarjmb.2023.v04i04.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2023.v04i04.001","url":null,"abstract":"Dyslipidemia is well known factor to increase incidence of heart diseases. This may lead to development of atherosclerotic plaques which is major etiological factor for establishing coronary artery disease (CAD). Hypolipidemic drugs used in allopathy include Statins, Fibric acids, Niacin, and Resins but all have their low compliance due to frequent side effects. Medicinal herbs like Onion and Ginger are hypolipidemic agents commonly used as flavoring agents and making foods spicy and tasty. We have compared hypolipidemic potential between these two medicinal herbs. The study was conducted at Ghurki Trust teaching hospital, Lahore from January to June 2016. Eighty secondary hyperlipidemic patients were enrolled after getting written consent which was approved by Ethics committee of the hospital. They were divided in two equal groups comprising 40 patients in each group. Group-I was treated by Ginger 10 grams daily in three divided doses for 2 months. Group-II was advised to take Onion 200 grams daily in divided amount with each meal i.e.; breakfast, lunch, and dinner for two months. After two months therapy it was observed by statistical analysis that 10 grams ginger reduced TC (total cholesterol) of 38 hyperlipidemic patients 12.4 gm/dl and LDL-C (low density lipoprotein cholesterol) 27.3 mg/dl. In group-II, onion reduced TC in 35 patients 17.9 mg/dl and LDL-C 14.8 mg/dl. Changes in tested parameters are significant biostatistically with p-values <0.01 to <0.001. We concluded from this research work that Onion and Ginger reduces risk of CAD by decreasing plasma total","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139308269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal Seeds for Lowering Low Density Lipoprotein Cholesterol and to Increase High Density Lipoprotein Cholesterol","authors":"S. Zafar, M. Iqbal, R. Zafar, Z. H. Tanveer, Syed Zeeshan Hyder Naqvi, Ume-Kulsoom Javed, Afsheen Mushtaq Shah, Farzana Majeed, Shaher Murad","doi":"10.36346/sarjmb.2023.v04i04.002","DOIUrl":"https://doi.org/10.36346/sarjmb.2023.v04i04.002","url":null,"abstract":"Having high levels of fat in you blood can lead to fatty deposits in the blood vessels in the body, including the coronary arteries (the blood vessels which supply the heart muscle with blood). This leads to the narrowing or hardening of the coronary arteries. Abnormal lipids are associated with increased risk for cardiovascular disease. So by making sure your lipids are well controlled, you are taking a powerful step to protect yourself from cardiovascular disease, including heart disease and stroke. The research work was single blind placebo-controlled, conducted at Jinnah Hospital, Lahore It was conducted from January 2018 to June 2018. Seventy five already diagnosed primary and secondary hyperlipidemic patients were selected with age range from 17 to 65 years. Diabetes mellitus, cigarette smoking/alcohol addictive patients, peptic ulcer disease, hypothyroidism, kidney dysfunction, any heart disease and liver disease. All patients were divided in three groups (group-I, group-II, group-III), 25 in each group. All participant’s baseline lipid profile data were taken and filed in specifically designed Performa, at start of taking medicine. Twenty five patients of group-I were advised to take 10 grams of Flaxseeds in three divided doses after meal. Twenty five patients of group-II were advised to take Ajwain seeds 10 grams in three divided doses after each meal for two months. Twenty five patients of group-III were provided placebo capsules, (containing grinded rice), taking one capsule after each meal. All participants were advised to take these medicines for eight weeks. Followup period: All participants were called fortnightly for their query and follow up. Their LDL- cholesterol, and HDL-cholesterol was determined at the hospital laboratory. In two months therapy by Flaxseeds decreased LDL-cholesterol from 195.11±2.11 mg/dl to 190.22±3.11 mg/dl, which is significant statistically. HDL was increased from 34.53±1.65 mg/dl to 38.97±2.29 mg/d, which is also significant change. In two months therapy by AJWAIN, LDL-c reduced from 201.51±2.62 mg/dl to 197.11±2.66 mg/dl, which is significant statistically. HDL- cholesterol increased by Ajwain from 36.97±3.32 mg/dl to 37.45±1.87 mg/dl, which is insignificant statistically. It was concluded from this study that Flaxseeds have more effect on HDL-c but Ajwain has lowest effect on this parameter.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139309003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethics and Regulation in Bionanotechnology: A Step Further in Ethical Rules and its Applications","authors":"Oghenetejiri Ukochovwera, Eloho Ukochovwera Ologan","doi":"10.36346/sarjmb.2023.v04i03.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2023.v04i03.001","url":null,"abstract":"Nanobiotechnology can be defined as the interconnection between technology and nanoscale. Many questions have been raised on ethical and regulatory issues. This has to do with the safety of humans and the environment. In nano biotechnology their a lot of risks and benefits in nanobiology. The EU Commission intends to place nanobiotechnology in the structure. The development of bionanotechnology is fast-growing including the ethical issue. This write-up shows the importance of ethical issues in bionanotechnology, these ethical issues cut across all other fields in biotechnology. In nanotechnology, there is a lot of implication that affects society and human. There is a difference in great impact but many needs to know more about nanotechnology. Some researchers are researching ethical and societal problems.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127136162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemistry in Homoeopathic System of Medicine","authors":"Tridibesh Tripathy, S. Das, D. R. Sahu, R. Dwivedi, Mohini Gautam, Umakant Prusty, M. Mishra, Pramod Bihari Pradhan","doi":"10.36346/sarjmb.2023.v04i02.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2023.v04i02.001","url":null,"abstract":"Background [1-3, 10, 20]: When Dr. John Paterson (1890-1955) of United Kingdom read out his paper on ‘Bowel Nosodes’ to the Rodanienne homoeopathic society at the meeting of the International Homoeopathic League Council in August 1949 at Lyon, France, he actually brought out the relation between biochemistry and homoeopathy. He not only presented the clinical aspects of the ‘bowel nosodes’ but also the biochemical analysis of each of the nosodes. Although Dr. Jacob Moleschott (1832-1893) and Dr. Justus Von Liebig (1803-1873) were the motivators to lay the fundamentals of biochemistry, the motivation could lead to the introduction of Biochemic system of medicine into homoeopathic therapeutics by Dr. Wilhelm Heinrich Schussler (1821-1898) after 24 years of Dr. Paterson’s efforts i.e. in 1973. Dr. Schussler introduced more and more biodynamic explanations for therapeutics of mineral salts. The Biochemic system of medicine or the inorganic cell salt therapy is the oldest form of nutraceutical therapy approved and recognised by the World Health Organisation (WHO) as one of the complementary therapies. Dr. Schussler developed the Schussler tissue remedies using an unique system of cellular therapy, biochemistry (the chemistry of living tissues) which continue to be popular in homoeopathic therapeutics in current times. As each & every drug in Homoeopathy is only proved on human beings, all the drugs have a mental component as it is only human beings who can express their physical & mental symptoms during proving of the drugs as per the guidelines set by the Homoeopathic Research Councils (HRC) of each nation. In India, Central Council for Research in Homoeopathy, an autonomous body under the ministry of AYUSH lays out such guidelines. The article gains more relevance during the current COVID 19 pandemic which has precipitated the stress levels of population since March 2020 and most of them are more prone to physical and mental disorders during their life stage thus disturbing the biochemistry of the body. The biochemic system of in homoeopathic therapeutics tries to restore this disturbed biochemistry.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128331750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Biological Screening of Novel Derivatives of Benzothiazol as Anticonvulsant Agents","authors":"Rachana B. Lamkane, Priyanka M. Khadasare, Pooja M. Shinde, T. P. Yele, Amarja B. Mohite, Priyanka B. Parekar, Shivraj S. Shivpuje","doi":"10.36346/sarjmb.2023.v04i01.002","DOIUrl":"https://doi.org/10.36346/sarjmb.2023.v04i01.002","url":null,"abstract":"The Benzothiazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of benzothiazole and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of bezothiazole obtained from 3-chloro-4-flouro aniline treated with potassium thiocynide with chloro acetyl chloride gives (7-chloro-6-fluro-1,3-benzothiazol-2-yl) acetyl chloride which is converted into hydrazide and yields the resultant compound derivatives of 2-(7-chloro-6-fluro-1,3-benzothiazol-2-yl) –N’-[(Z)-phenyl methylidene] acetohydrazide (SMVB-IIIA-IIIG).Title compound were synthesized and the structures of newly synthesized compounds were confirmed by IR, Mass and 1H-NMR spectroscopy All the compounds synthesized were confirmed by spectral data and evaluated for their anticonvulsant activity. The Compounds SMVB-IIIC, SMVB-IIIEand SMVB-IIIF showed maximal activity whereas remaining compounds showed good activity.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130757649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Activity of Ethanolic Leaves Extract of Andographis paniculata on Isolates of Salmonella spp. and Escherichia coli from Locally Processed Beverages in Umueze Nkanu West Local Government Area Enugu State Nigeria","authors":"Iloputaife Emmanuel Jaluchimike, Mba-Omeje Nkechinyere, Aneke Chinwe Jacinta","doi":"10.36346/sarjmb.2023.v04i01.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2023.v04i01.001","url":null,"abstract":"The microbial contamination of locally processed beverages has been familiar among microbiological researchers who have repeatedly implicated them as the major cause of endemics due to poor processing. However, due to antimicrobial resistance and the need to discover new antimicrobial plants, Antibacterial activity of ethanolic leaf extracts of Andographis paniculata against isolates of Salmonella spp. and Esherichia coli from zobo and soya milk was studied. Andographis paniculata leaves were collected randomly from a local farm in Emene Enugu East L.G.A Enugu State. The leaves samples were identified morphologically, washed, air dried at room temperature and milled into powder. 39.7 g of the powder was macerated with ethanol during the extraction process. Phytochemical analysis was carried out on the extract and result showed that Saponins, Tanins, Flavanoids, Phenols, Steriods were present with Flavanoids and Saponins being in higher concentration, while Terpernoids, Alkaloids and Glycosides were absent. The zobo and soya milk samples were diluted using 10-fold serial dilution method and introduced into the already prepared MacConkey and Salmonella Shigella Agar for incubation. Isolates from zobo and soya milk were characterized, biochemically and morphologically and were identified as E. coli and Salmonella spp. Antibacterial activity of ethanolic leaf extracts of A. paniculata against E. coli and Salmonella spp. was determined using agar well diffusion method, and result showed that there was no antibacterial activity of ethanolic leaf extracts of A. paniculata against E. coli and Salmonella spp. However, absence of Terpernoids, Alkaloids and Glycosides exhibited non-comparable activity with the positive control (ciprofloxacin).","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126504522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mask Mouth Syndrome—Pros and Cons","authors":"Dr.Anil Batta, Umesh Kumar, Preeti Sharma","doi":"10.36346/sarjmb.2022.v03i05.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2022.v03i05.001","url":null,"abstract":"Recent studies suggest that coronavirus disease 2019 (COVID-19) may be transmitted by infected persons even in the absence of symptoms of disease. While social distancing and good hand hygiene are the most important methods to prevent virus transmission, new guidelines state that healthy individuals can consider wearing masks in public settings, particularly when physical distancing is difficult (like in grocery stores or pharmacies). Primary benefits of wearing a mask include limiting the spread of the virus from someone who knows or does not know they have an infection to others. Masks also remind others to continue practicing physical distancing. However, nonmedical masks may not be effective in preventing infection for the person wearing them. Masks should not be worn by children younger than 2 years or by individuals who are unable to remove the mask by themselves or are unconscious.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131195562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa oliefera Leaves Powder Controlling Blood Glucose Level in Diabetes Mellitus Patients , No Side Effect in Kidney and Liver Enzymes","authors":"Noor Elsham A. Yousif, Shaza O. Mustafa, Eman. Z. E. Yassin, Fania. A. Albdari, M. Hamad","doi":"10.36346/sarjmb.2022.v03i04.001","DOIUrl":"https://doi.org/10.36346/sarjmb.2022.v03i04.001","url":null,"abstract":"Moringa oleifera grown and used in many countries around the world is a multi-purpose tree with medicinal and nutritional values. This study evaluates the effect of taking moringa oleifera leaves powder on blood sugar levels in humans, and study side effect on kidney (urea, creatinine) and liver enzyme (AST, ALT) after taken leaves powder for a month. The study targeted patients who their blood glucose not lowering by drugs. Blood glucose, urea, creatinine, AST and ALT for all diabetic patients was determined before and after taking 0.5g leaves powder. Results showed blood sugar levels decreased statistically significant (p<0.001) for all diabetic patients, and no statistically significant difference in the mean values of urea, creatinine, (AST) and (ALT) before and after taking leaves powder (p˃0.001). This study concluded that leaves powder have a significant impact on anti-diabetic property for the selected patients, so it's promising in the prevention for risk of diabetes mellitus.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128959051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Shisha (Water-Pipe) Smoking on Serum Lipid Profile and Antioxidant Vitamins among Smokers in Kano Metropolis","authors":"I. M., Waziri B I, A. A, Atiku M K","doi":"10.36346/sarjmb.2022.v03i03.005","DOIUrl":"https://doi.org/10.36346/sarjmb.2022.v03i03.005","url":null,"abstract":"Shisha Smoking is a risk factor for coronary heart diseases. The smoke contains large amount of chemicals which are capable of generating reactive oxygen species which play an important role in oxidative stress which in turn leads to the development and progression of many disorders such as hypertension, cancer, diabetes mellitus and cardiovascular diseases. Monitoring lipid profile (HDL-cholesterol, LDL-cholesterol and triacylgycerides) and antioxidant vitamins (A, C and E) levels is very important to give an insight on the effect of shisha smoking on lipid profile and antioxidant vitamins. This study aimed to determine the effect of shisha smoking on serum lipid profile, and antioxidant vitamins in fifty (50) apparently healthy shisha smokers (exposed group) in Kano metropolis. A corresponding fifty (50) apparently healthy non-smokers were used as controls (non exposed group). The Shisha smoking was significantly associated with increased levels of total cholesterol (TC), triglyceride, LDL-cholesterol (p˂0.05) in smokers compared to control group. However, there was a significant (p>0.05) decrease in HDL-cholesterol and serum antioxidant vitamins (A, C and E) in exposed group compared to non-exposed group. The results of this study also indicate that exposure of human being to shisha smoke over a period of time causes slight increase in lipid profile and antioxidant vitamins but the relation was statistically not significant (p>0.05). The findings suggest that shisha smoking causes dyslipidaemia and oxidative stress.","PeriodicalId":122039,"journal":{"name":"SAR Journal of Medical Biochemistry","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114778928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}