内皮素和应激指数是COVID- 19严重程度预后的新决定因素之一

Maha Abubakr Feissal Rabie, M. Gaber, Mostafa Soula, Inas M Masoud
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摘要

入住重症监护病房(ICU)。完成全血检查,包括差异计数、c反应蛋白、铁蛋白、d -二聚体、肝肾功能、乳酸脱氢酶、心脏标志物、EASIX、胸部CT、ECG、Echo。结果:EASIX与d -二聚体和铁蛋白作为COVID-19死亡率、ICU住院需求和机械通气预测指标的敏感性和特异性具有统计学意义,而淋巴细胞/单核细胞比(LMR)仅对COVID-19死亡率和ICU住院需求的敏感性和特异性具有统计学意义。d -二聚体的总体准确度最高,其次是铁蛋白、EASIX, LMR的准确度最低。结论和建议:由于ESAIX与COVID-19死亡率的相关性较强,因此应将其作为新的生物标志物加入到现有的与预后不良相关的生物标志物d -二聚体和铁蛋白中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endothelail and Stress Index as One of New Prognostic Determinants of COVID- 19 Severity‎‎
stay, and intensive care unit (ICU) admission. Complete blood picture with differential count, C-reactive protein, ferritin, D-Dimer, liver and renal function tests, lactate dehydrogenase, cardiac markers, EASIX, chest CT, ECG, and Echo were done. Results: EASIX along with D-Dimer and ferritin showed statistically significant sensitivity and specificity when analysed as predictors for COVID-19 mortality, need for ICU admission and mechanical ventilation, while lymphocyte/monocyte ratio (LMR) showed statistically significant sensitivity and specificity only for COVID-19 mortality and need for ICU admission. D-Dimer had the highest overall accuracy, followed by ferritin, EASIX, and the lowest accuracy appear in LMR. Conclusion and recommendation: Because of its strong correlation with COVID-19 mortality, ESAIX should be added as a new biomarker to the existing set of biomarkers linked to poor prognosis namely D-Dimer and ferritin .
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