尼日利亚阿布贾大学教学医院孕妇血小板指数分析

A. Dangana, A. Emeribe, Hezekiah Alkali Isah, S. Musa, J. Abu, Solomon Oloche Onoja, N. Onukegbe, I. Abdullahi
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引用次数: 1

摘要

血小板通过在损伤部位聚集而开始止血,并参与确保内皮细胞的完整性。这一过程中的缺陷可能导致血管内失血。本病例对照研究旨在确定尼日利亚阿布贾瓜瓦拉达阿布贾大学教学医院孕妇的血小板计数和指标。本研究共纳入120名孕妇作为病例,60名非孕妇作为对照。采用EDTA管采集血样,全自动五分式血液学分析仪进行全血小板计数及各项指标检测。孕妇血小板计数的平均值±标准差为226.54±69.76 109 cells/L,与非孕妇的平均值214.95±52.22x 109 cells/L差异无统计学意义(p=0.295)。两组平均血小板体积(MPV)差异有统计学意义(p=0.036)。经事后检验,妊娠晚期孕妇与对照组比较,差异有统计学意义(p=0.014)。然而,在大细胞比例和血小板分布宽度方面,病例组和对照组没有差异。病例组15例(11.0%),对照组7例(12.1%)有轻度血小板减少。然而,妊娠状态与血小板减少无显著相关性(p=0.836)。由此可以推断,与非妊娠妇女相比,随着孕龄的增加,血小板计数和MPV减少,而PDW增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Platelet Indices Profile of Pregnant Women Attending University of Abuja Teaching Hospital, Nigeria
Platelets initiate hemostasis by aggregating at the site of injury and participate in ensuring endothelial integrity. A defect in this process could lead to intravascular blood loss. This case-control study sought to determine the platelet counts and indices among pregnant women in the University of Abuja Teaching Hospital Gwagwalada, Abuja, Nigeria. A total of 120 pregnant women as case and 60 non-pregnant women as control were enrolled for this study. Blood samples were collected in EDTA tubes, and complete platelet count and indices were carried out using an automated five-part haematology analyzer. The mean ± standard deviation of the platelets count among the pregnant women, 226.54 ± 69.76 109 cells/L was not significantly different from that of the non-pregnant women, 214.95 ± 52.22x 109 cells/L (p=0.295). There was a significant differences in mean platelets volume (MPV) of the case and control groups (p=0.036). After post-hoc test, the significant difference was between the  pregnant women in 3rd trimester and the control group (p=0.014). However, there was no diffences in the mena platelets larger cell ratio and platelet distribution width in the case and control groups. Fifteen (11.0%) and 7 (12.1%) of the case and control control groups, respectively had mild thrombocytopenia. However, there was no significant association between pregnant status and thrombocytopenia (p=0.836). Based on these findngs, it can be infered that platelet count and MPV decreases while PDW increase with the progression of gestation age compared to the non-pregnant women.
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