Histopathological Evaluation of Malignant Adult Renal Tumors-A Study of Specialized Tertiary Care Center

Background: According to the recent World Health Organization (WHO), renal cell carcinomas (RCCs) that primarily affect adults and 2.2% of all new malignancies and 1.8% of all cancer deaths. Majority of the cases, the diagnosis of RCCs and its subtype can be based on histomorphological evaluation. Accurate pathological classification along with staging and grading of the tumor are necessary for prognosis and various therapeutic options. Materials and Methods: It was a retrospective observational study. This study conducted in histopathology department of the Center for Kidney Disease & urology (CKD & Urology) Hospital, Dhaka, Bangladesh. The study period was eight month from February 2021 to September 2021. The specimens were both partial and total nephrectomy sample of more than 38 years of aged patients. Results: Total 62 nephrectomy specimens were received. Fifty seven (57) cases were malignant tumor and five cases were benign lesions. Majority of malignant tumor consisting of clear cell type renal cell carcinoma 37 (64.91%), followed by papillary type 12 (21.05%), Chromophobe (8.77%), two cases (3.5%) were sarcomatoid cell type and one case (1.75%) of Multiloculated Cystic Renal Neoplasm was noted. Renal cell carcinoma was seen in age range of 38 to 78years with 32 (56.14%) patients more than 50 years of age. Total 42 (73.68%) cases were ISUP Grade 1 and 2 and majority cases were (66.66%) presented at AJCC stage (pT2). Conclusion: In conclusion we observed significant increased clear cell type renal cancer in our institution based population. There was similar male to female ratio, mean tumor size as well as Grade 1, 2 and Stage pT 2 as compared to other studies.