生物晶体组学作为创新生物医学技术的基础

A. Martusevich, S. Kosyuga, L. Kovaleva, A. Fedotova, A. Tuzhilkin
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引用次数: 1

摘要

生物结晶现象已经被研究人员记录了一个多世纪。同时,尽管这一领域的经验数据众多,但对于所考虑的方向却没有统一的理论依据。在此基础上,综述的目的是将生物晶体组学作为一门新的综合生物医学科学的概念系统化,该科学详细而完整地考虑了生物相关结晶在体外和体内发生的过程。本文介绍了俄罗斯有关人畜生物体液游离结晶和初始结晶研究的历史基础和现状。阐述了生物晶体学的主要建设阶段、基本规律和从生物晶体学向生物晶体组学转变的问题。介绍了这门学科的定义,主要任务的特点。介绍了生物晶体组学研究的主要方向,包括实验生物晶体组学、晶体诊断学、晶体病理学、晶体治疗、药物生物晶体组学和晶体指征。对现有的生物晶体发生的研究方法进行了详细的综述,将其分为三大类:晶体学、tezigraphgraphy和实验晶体学。特别注意决定生物流体结晶特征的因素,其中区分了物理、化学、生物和混合。揭示了生物晶体发生在生物系统中的5大功能:保护功能、营养代谢功能、致病功能、信息功能和合成生物功能。介绍了生物晶体组学的整体理论及其主要规定。因此,对生物晶体组学作为一门新兴的生物晶体综合科学进行了描述,并给出了其发展的一般途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biocrystallomics as the basis of innovative biomedical technologies
The phenomenon of biocrystallization has been recorded by researchers for over a century. At the same time, despite the presence of numerous empirical data in this area, there is no unified theoretical basis for the direction under consideration. On this basis, the purpose of the review is to systematize the concepts of biocrystallomics as a new synthetic biomedical science that considers in detail and integratively the processes of bio-associated crystallization occurring both in vitro and in vivo. In this paper historical basis and current status of Russian investigations, which associated with human and animal’s biological fluids free and initiated crystallogenesis, are shown. Main stages of building, fundamental rules and problem aspects of biocrystallography as a transformation it to biocrystallomics causes are demonstrated. The definition of this science is presented, its main tasks are characterized. The main directions of biocrystallomics are described, which include experimental biocrystallomics, crystallodiagnostics, crystallopathology, crystallotropic therapy (crystallotherapy), pharmacobiocrystallomics and crystal indication. The existing methods of studying biocrystallogenesis are considered in detail, which are grouped into 3 categories: crystalloscopic, tezigraphic and experimental crystalloscopic. Special attention is paid to the factors that determine the features of the crystallization of biological fluids, among which physical, chemical, biological and mixed are distinguished. The 5 main functions of biocrystallogenesis in biological systems are revealed: protective, nutritive-metabolic, pathogenetic, informational and synthetic-biogenic. The holistic theory of biocrystallomics and its main provisions are presented. So, biocrystallomics as a new integrative science about biocrystals is characterized, and its general ways are given.
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