Polycystic ovary syndrome: Impact of obesity and aging on the profile of gonadotrophin and adrenal hormones

Many studies have been conducted to understand thoroughly the mechanism of polycystic ovaries syndrome (PCOS), but very few of them came from Africa. The aim of this study, was firstly to make a diagnostic of this syndrome, according to Rotterdam criteria, and secondly to assess the correlation of obesity and age on this pathology. The study was conducted at Bouake, within the medical School and Hospital, during the period, September 2014 to January 2016. All participants have been diagnosed with PCOS on the basis of the Rotterdam criteria. The mean age was 25.37 ± 5.47 and the mean body mass index (BMI) was 28.82 ± 8.51 kg/m2. There were either significant or no significant statistical differences about parameters value concerning age or BMI into the population. There was no significant statistical difference between age and BMI. Otherwise the overweight and obese patients were both present in the group under 25 years old and in the group having above 25 years old. The differences related to the mean value of hormonal parameters were observed in the two populations according to the BMI range. The mean value of testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) has increased according to the augmentation of BMI and age. Contrary to this trend, the mean value of estradiol and sex hormone binding globulin (SHBG) has decreased in the same conditions. The data suggest that in everyday practice, the collaboration between clinician and biologist must be built up in order to make early the diagnosis of PCOS among infertile women. Key words: Polycystic ovaries syndrome, obesity, age, gonadotrophin, adrenal hormones.