铬铁矿地下开采工人的免疫调节特征

O. Dolgikh, K. Starkova
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引用次数: 0

摘要

对从事地下铬铁矿开采的工人免疫调节特征的研究表明,与生理正常值相比,25.7%的工人血清铬水平高与吞噬活性增加有关。吞噬指数标准也可靠地改变了吞噬活性,与对照组相比,绝对吞噬量和相对吞噬指数显著增加(1.2-1.33倍)。IgM水平比参考值低1.2倍,与IgG缺乏和IgA产量增加有关。作者还揭示了细胞亚群平衡和t细胞受体转化的变化,在主要工作组中,90.0%的调节标志物CD95下降,CD4+CD25+CD127淋巴细胞数量增加,CD3+和CD4+细胞分别比对照组增加1.5倍和1.2倍。其他研究发现,与正常值相比,50.0% - 62.5%的工人通过降低fas受体的表达和改变调节蛋白Bcl-2和Bax的平衡而导致细胞凋亡的启动和调节紊乱,Bax水平比对照组增加了2.6倍。
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Immune regulation features in workers engaged into underground mining of chromite ores
The study of immune regulation features in workers engaged into underground mining of chromite ores demonstrated that high serum chromium levels were associated with increased phagocytic activity, if compared to physiologic normal values, in 25.7% of the workers. Findings also are phagocytic activity reliably changed by phagocytic index criterion, and significantly (1.2–1.33 times) increased absolute and relative phagocytosis and phagocytic index vs. the reference group values. IgM levels appeared 1.2 times lower vs. the reference group values, in association with IgG deficiency and increased IgA production vs. the reference values. The authors also revealed changes in cellular subpopulations balance and T-cell receptors transformation, with depressed regulatory marker CD95 in 90.0% in the main group workers, and higher number of CD4+CD25+CD127 lymphocytes, increased CD3+ and CD4+ cells 1.5- and 1.2-fold respectively vs. the reference group values. Other findings are disordered launching and regulation of apoptosis via lower Fas-receptor expression and changed balance of regulatory proteins Bcl–2 and Bax vs. the normal value in 50.0–62.5% of the workers, with reliable 2.6-fold increase of Bax level vs. the reference group.
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