Vitamin D3: Emerging Role in Murine Toxoplasmosis ‎

Materials and Methods: The study was conducted on 100 Swiss albino mice which were infected with the avirulent (ME49) Toxoplasma gondii strain. Mice were equally divided into 5 groups: (GI): Infected untreated control group; (GII): Infected and treated by spiramycin; (GIII): Infected and treated by vitamin D3; (GIV): Infected and treated by nitazoxanide and (GV): Infected and received a (vitamin D3 –nitazoxanide) combination. The therapeutic impacts of drugs were assessed using; parasitological, histopathological and immunological approaches. Results: The study showed that the vitamin D3nitazoxanide combination induced a significant reduction in the parasitic load in the brain sections of the infected mice. We have also reported a delicate balance in the overall immune response against the parasite after using the drug combination. It was noted that vitamin D3, used alone, did not significantly reduce the parasitic load despite the notable improvement in the degree of inflammatory infiltration.